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We tend to think of Alzheimer’s and dementia as tragedies reserved for the elderly. But Neurophysiologist Louisa Nicola argues that the "silent onset" of brain decline begins thirty years before the first symptom appears. In this episode of Synthesize, we deconstruct the neurophysiology of aging and the specific protocols to stop it. From the surprising link between your leg muscles and brain volume to the "washing machine" mechanism of the Glymphatic system, this visual breakdown reveals how to physically intervene in your own cognitive destiny. We explore why the "Active Sedentary" lifestyle is a metabolic disease, how to use creatine to survive sleep deprivation, and how to physically grow the part of your brain responsible for willpower. This is Synthesize — where we turn long podcast conversations into their most important ideas. TIMESTAMPS: 00:00 – The Silent Onset (Alzheimer's starts in your 30s) 00:48 – The Genetic Myth 01:36 – The Muscle-Brain Axis (Legs as a battery) 02:35 – The "Active Sedentary" Trap 03:30 – The 10-Squat Rule (Metabolic Fix) 04:12 – Biological Time Travel (Reversing Heart Age) 05:07 – The Nightly Rinse (Glymphatic System) 06:00 – Creatine: The Cognitive Cheat Code 07:08 – The Anatomy of Willpower (Building the AMCC) 07:58 – Conclusion: Training for Identity ORIGINAL INTERVIEW: This video is a condensed adaptation of the conversation between Steven Bartlett and Louisa Nicola on The Diary of a CEO. Watch the full episode here: • Cognitive Decline Expert: The Disease That... #Neuroscience #BrainHealth #LouisaNicola #Longevity #AlzheimersPrevention #Synthesize