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⚠️ MEDICAL EDUCATION DISCLAIMER This video provides educational information about the gut microbiome and its relationship to cancer prevention and immune function. All recommendations are based on peer-reviewed research and clinical experience, but should not replace personalized medical advice. Always consult your healthcare provider before making changes to your health regimen, especially if you have existing conditions or take medications. Individual results may vary. This content is intended for adults 65+ interested in evidence-based health information. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ Scientists can now predict colorectal cancer risk by analyzing gut bacteria alone — no colonoscopy, no biopsy. And 50–60% of colorectal cancer cases after 65 are tied to completely modifiable factors. The bacteria living in your gut right now are either training your immune system to destroy abnormal cells — or failing to. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 🔴 Key Topics Covered: → How specific gut bacteria (Akkermansia, Bifidobacterium, Faecalibacterium) activate anti-cancer immune cells → Why butyrate — produced by your gut microbiome — can switch tumor suppressor genes back ON → The exact foods shown in a Stanford Cell study to reduce 19 inflammatory biomarkers in just 10 weeks → Why seniors over 65 face a steeper microbiome decline — and exactly how to reverse it → How PPIs, antibiotics, and common senior medications are silently destroying your gut bacteria → A 6-step protocol (fiber, fermented foods, plant diversity, medication audit, exercise, sleep) specifically optimized for adults 65–80 What if your immune system's ability to detect and destroy cancer cells depends less on genetics — and more on what you ate for breakfast? 📚 RESEARCH CITED IN THIS VIDEO: Primary Studies: ● Gut Microbiome & Colorectal Cancer (Gut, 2023) Akkermansia muciniphila reprograms the tumor microenvironment via acetyltransferase activity. ● Wastyk et al. (Cell, 2021) High-fermented-food diet reduces 19 systemic inflammation biomarkers in 10 weeks. ● npj Biofilms and Microbiomes (2025) Systematic review: Bifidobacterium and Akkermansia predict immunotherapy response in melanoma, lung, and renal cancers. ● Sonnenburg Lab / American Gut Project Plant diversity (30+ types/week) strongly correlates with microbiome richness. ● HDAC Inhibition by Butyrate in CD8+ T Cells (2024) Butyrate reactivates tumor-suppressed T cells by inhibiting HDAC3 and HDAC8. ● Faecalibacterium prausnitzii Decline in Aging Adults Longitudinal studies documenting ~40% decline in butyrate- producing bacteria in adults over 65. ● PPI & Antibiotic Effects on Senior Microbiome (Meta-Analysis, 2023) Chronic PPI use produces microbiome disruption comparable to antibiotic courses in adults over 60. Medical Organizations Referenced: ● American Institute for Cancer Research (AICR) Dietary guidelines for colorectal cancer prevention; 30g fiber/day recommendation. ● International Agency for Research on Cancer (IARC/WHO) Group 1 carcinogen classification for processed meats. ● European Prospective Investigation into Cancer and Nutrition (EPIC) Whole grain intake associated with 17% reduced colorectal cancer risk per 90g/day. ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 👨⚕️ ABOUT DR. WILLIAM BENNETT: Dr. William Bennett is a physician with over 20 years of clinical experience dedicated to senior health and preventive medicine. This channel exists to give adults 65+ the honest, complete, science-based health conversations you deserve — the information doctors discuss among themselves but don't always have time to share in a 15-minute appointment. New videos every week on senior health, preventive medicine, and evidence-based longevity. 🔔 Subscribe so you never miss a video: 👍 Like if this information was valuable to you 💬 Comment your biggest takeaway or question below #DrWilliamBennett #SeniorHealth #HealthOver65 #PreventiveMedicine #EvidenceBasedHealth #GutHealth #Microbiome #CancerPrevention #ColonCancer #GutBacteria #Akkermansia #Butyrate #ImmuneHealth #GutImmunity #Inflammation #Inflammaging #HealthyAging #WellnessOver65 #HealthyLifestyle #FunctionalMedicine #Longevity #HealthSpan #BiologicalAge #FermentedFoods #ColonHealth #SeniorWellness #AgingWell #HealthOver70 #GutMicrobiome #ColorectalCancer #ImmuneSystem #BuytarateRichFoods #GutBrainAxis #Bifidobacterium #FaecalibacteriumPrausnitzii #SeniorNutrition #HealthAfter65 #MedicalEducation