Patho-Physiology of Urticaria: Role of Mast Cells, Basophils, Eosinophils, and Auto-Antibodies скачать в хорошем качестве

Patho-Physiology of Urticaria: Role of Mast Cells, Basophils, Eosinophils, and Auto-Antibodies

Hi. With this video, we will discuss the pathomechanism of Urticaria and Angioedema, along with the role of Mast Cells, Basophils, and Eosinophils. We will also discuss the role of IgE and IgG Auto-Antibodies, preformed mediators in urticaria. We will also learn about Basophil Activation Test [BAT] and Basophil Histamine Release Assay [BHRA]. This video is directed towards dermatologists and is not at all advisory for non-medical personnel. Triple Response of Lewis - 03:51 Introduction - 06:44 Epidemiology - 09:16 Endotypes of Urticaria - 10:32 Pathomechanism - 15:24 Mast Cells - 17:13 Degranulating Stimuli - 19:57 Preformed Mediators - 25:48 Blood Vessels - 31:28 Auto-Antibodies - 33:10 Basophils - 39:00 Basophils Activation Test [BAT] - 41:36 Basophils Histamine Release Assay [BHRA] - 44:07 Basophils - 39:00 Eosinophils - 46:00 Other Mediators - 48:37 Mechanism of Urticaria: Mast Cell Dependent - 50:20 Mechanism of Urticaria: Mast Cell Independent - 56:28 Mechanism of Angioedema - 58:52 Approach to Urticaria - 01:03:51 Approach to Angioedema - 01:05:05 Further Reading - 01:07:04 End - 01:07:58 Articles on the pathomechanism of urticaria: 1. Bolognia 4ed, Chapter 18: Urticaria and Angioedema. Pg – 304 2. Kirkpatrick CH. A mechanism for urticaria/angioedema in patients with thyroid disease. J Allergy Clin Immunol. 2012 Oct;130(4):988-90. doi: 10.1016/j.jaci.2012.05.017. Epub 2012 Jun 22. PMID: 22728088. 3. Altrichter S, Frischbutter S, Fok JS, Kolkhir P, Jiao Q, Skov PS, Metz M, Church MK, Maurer M. The role of eosinophils in chronic spontaneous urticaria. J Allergy Clin Immunol. 2020 Jun;145(6):1510-1516. doi: 10.1016/j.jaci.2020.03.005. Epub 2020 Mar 26. PMID: 32224275. 4. Kolkhir P, Muñoz M, Asero R, Ferrer M, Kocatürk E, Metz M, Xiang YK, Maurer M. Autoimmune chronic spontaneous urticaria. J Allergy Clin Immunol. 2022 Jun;149(6):1819-1831. doi: 10.1016/j.jaci.2022.04.010. PMID: 35667749. 5. Konstantinou GN, Riedl MA, Valent P, Podder I, Maurer M. Urticaria and Angioedema: Understanding Complex Pathomechanisms to Facilitate Patient Communication, Disease Management, and Future Treatment. J Allergy Clin Immunol Pract. 2023 Jan;11(1):94-106. doi: 10.1016/j.jaip.2022.11.006.