Inhaled CBD Boosts Acetylcholine in Alzheimer's Mice (Khodadadi et al., 2024) скачать в хорошем качестве

Inhaled CBD Boosts Acetylcholine in Alzheimer's Mice (Khodadadi et al., 2024)

I. Study Overview This video reviews new research on CBD and Alzheimer's disease. The study investigates the effects of inhaled CBD on mice. Researchers used a specific mouse model known as 5xFAD. The focus was on cognitive function and brain pathology. The treatment involved chronic inhalation for seven months. II. Impact On Cognitive Function Long-term CBD inhalation improved memory in mice. Treated mice performed better in Novel Object Recognition tests. They showed improved exploration in Open Field tests. The results suggest CBD may help reverse cognitive decline. This improvement aligns with reduced disease symptoms. III. Changes In Brain Chemistry CBD treatment increased acetylcholine levels in the hippocampus. Acetylcholine is a key neurotransmitter for learning. The study found a reduction in amyloid beta plaques. Neurofibrillary tangles were significantly reduced. These changes are markers of improved brain health. IV. Physiological Improvements Inhaled CBD significantly improved cerebral blood flow. Blood flow was measured using photoacoustic imaging. Better blood flow supports overall brain function. The treatment was non-invasive and well-tolerated. This suggests CBD supports vascular health in the brain. V. Immune System Regulation CBD altered the profile of innate lymphoid cells (ILC2s). It normalized ILC2 levels in the meninges and choroid plexus. Meningeal ILC2s produced more acetylcholine after treatment. This highlights an immune-cholinergic pathway. CBD may help regulate neuroinflammation through this mechanism. VI. Conclusions And Future Directions Inhaled CBD offers a promising, non-invasive therapy. It links immune regulation with the cholinergic system. The study supports the "cholinergic hypothesis" of Alzheimer's. Further research is needed to translate findings to humans. Clinical trials are required to test safety and efficacy. VII. Additional Resource Support See NourishED RFI's NotebookLM Resource Support Page. https://notebooklm.google.com/noteboo... VIII. Source Khodadadi, H., Salles, É. L., Naeini, S. E., Bhandari, B., Rogers, H. M., Gouron, J., Meeks, W., Terry, A. V., Jr., Pillai, A., Yu, J. C., Morgan, J. C., Vaibhav, K., Hess, D. C., Dhandapani, K. M., Wang, L. P., & Baban, B. (2024). Boosting Acetylcholine Signaling by Cannabidiol in a Murine Model of Alzheimer’s Disease. International Journal of Molecular Sciences, 25(21), 11764. https://doi.org/10.3390/ijms252111764 #AlzheimersResearch #CBD #Acetylcholine #Neuroscience #Dementia #BrainHealth #MedicalScience #Immunology #Cannabidiol #CognitiveHealth ‪@NIHgov‬ ‪@NIHVideoCast‬ ‪@NIH_NCCIH‬ ‪@BBRFoundation‬ ‪@nunmedu‬ ‪@TheAPAVideo‬ ‪@AmericanPsychiatricAssociation‬ ‪@PsychedelicsToday‬ ‪@yalepsychedelicsciencegrou9534‬ ‪@OxfordPsychedelicSociety‬ ‪@stanfordpsychedelicscience12‬ ‪@dalebredesen3092‬ ‪@AlzheimersResearchUK‬ ‪@alzassociation‬ ‪@alzheimerssociety‬ ‪@alzheimersresearchassociat2883‬ ‪@WisconsinADRC‬ ‪@NIHAging‬