У нас вы можете посмотреть бесплатно FPWR Funded Project: Role of MAGEL2 in melanocortinergic circuits and feeding regulation или скачать в максимальном доступном качестве, видео которое было загружено на ютуб. Для загрузки выберите вариант из формы ниже:
Если кнопки скачивания не
загрузились
НАЖМИТЕ ЗДЕСЬ или обновите страницу
Если возникают проблемы со скачиванием видео, пожалуйста напишите в поддержку по адресу внизу
страницы.
Спасибо за использование сервиса ClipSaver.ru
Dr. Jo and his team are working on appetite-controlling pathways in the brain, including the central melanocortin system. Research has shown that mice without the Magel2 gene have fewer proopiomelanocortin (POMC) neurons that produce melanocortins and have selective loss of function in POMC neurons. These specific neurons appear to express estrogen receptor-alpha (ER-alpha) and also regulate ER-alpha-expressing neurons located in the amygdala, and there is a potential role of the amygdala in food-seeking behavior and hyperphagia in PWS. Therefore, Dr. Tai and team believe that impaired POMC projection to ER-alpha-expressing neurons due to a loss of the Magel2 gene in POMC neurons induces hyperphagia. Understanding the cellular mechanisms underlying weight gain in PWS will lead to a more focused and successful management of and ultimately, treatment of overweight and obesity.