Total Synthesis of (+)-Aberrarone скачать в хорошем качестве

Total Synthesis of (+)-Aberrarone

In this video I talk about the synthesis of aberrarone, a natural product that bears a unique 6/5/5/5 tetracyclic ring system, four ketones, seven stereocenters, and three quaternary carbon centers. . For the synthesis of this diterpene, the authors envisioned the possibility of constructing the carboskeleton via a manganese-mediated intramolecular 5-exo/5-exo/5-exo radical cascade reaction. . Also in this video: Appel reaction: http://nrochemistry.com/appel-reaction/ Riley oxidation: https://nrochemistry.com/riley-oxidat... . Reference: J. Am. Chem. Soc. 2023, 145, 9459. https://doi.org/10.1021/jacs.3c02511