Pharmaceutics/Lecture-6 J/Aerosols/Valve Assembly/Product Concentrate/Propellants/Containers скачать в хорошем качестве

Pharmaceutics/Lecture-6 J/Aerosols/Valve Assembly/Product Concentrate/Propellants/Containers

Welcome to PharmaLecture – Your Trusted Source for Quality Pharmacy Education Aerosols Aerosols are pressurized dosage forms containing one or more than one active ingredients which upon actuation emit a fine dispersion of solid and liquid in gaseous form. Components of Aerosols 1. Propellant 2.Container 3.Valve assembly and actuator 4. Product concentrate 1.Propellants These are chemical substances which are responsible for developing pressure within a container and expel the product when valve is open. Commonly used propellants Butane, isobutane, Chlorofluorocarbons( difluoroethane, dichlorotetrafluoroethane) Containers Containers are available in tin plate, aluminum, stainless steel and glass material. 3.Valve Assembly Function of valve assembly is to permit the expulsion of contents of containers: 1 In desired form 2 In proper amount or dose it has following parts 1. Mounting cup Used to attach the valve properly to the container, made of tin. Aluminum can also be used. 2. Housing It contains an opening at the point of attachment of dip tube. It is made of nylon. 3. Stem It supports actuator and delivers the product in proper form. Made of nylon, brass and steel. 4. Gas kat It is used to prevent leakage of formulation from container. Made of rubber. 5. Spring Used to hold gas kat in plate. When actuator is depressed and released it returns the valve to its close position again. 6. Dip tube It is used to bring formulation from container. Its diameter vary from formulation to formulation. 7. Actuator Its function is to deliver the aerosol product in proper and desired form. 1 Spray actuator (Dispersing product into relatively small particles) 2 Foam actuator (Large orifice) 3 Solid actuator (Relatively large orifice used for semi-solid products) 4 Specially designed actuator ( For appropriate site as nasal, throat, eye) Metered Valve These are valves which allow specific amount of product to come out and then stop automatically. Such valves contain reservoir of specific volume which on actuation empties all the contents present in it on single push of actuator. e.g. metered dose inhaler (MDI) 4.Product Concentrate It consist of: Active ingredient, Solvent system, Preservative/ Anti-oxidant, surfactants. for any question whats app +923038489485 Email jspharma116@gmail.com Subscribe now and equip yourself with the knowledge and confidence to succeed in the dynamic field of pharmacy.