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A viral social media trend turned a common allergy medication into a life-threatening risk. The so-called “Benadryl challenge” on TikTok has led to emergency room visits, hospitalizations, and tragic deaths among teenagers chasing hallucinations for online views. Diphenhydramine, the active ingredient in Benadryl, is safe when used as directed. But in high amounts, it can cause severe heart problems, seizures, dangerous changes in blood pressure, coma, and death. Health officials, including the U.S. Food and Drug Administration (FDA), have issued public warnings about the dangers of misusing over-the-counter medications for viral challenges. Adolescents are particularly vulnerable, as social media algorithms amplify risky trends and peer pressure fuels participation. Resources: FDA Warns About Serious Problems with High Doses of the Allergy Medicine Diphenhydramine (Benadryl) – U.S. Food and Drug Administration – https://www.fda.gov/drugs/drug-safety... Diphenhydramine Overdose – MedlinePlus (U.S. National Library of Medicine) – https://medlineplus.gov/ency/article/... America’s Poison Centers: Diphenhydramine Misuse Alert – America’s Poison Centers – https://poisoncenters.org/track/diphe... Adolescent Risk Behaviors and Overdose Data – Centers for Disease Control and Prevention – https://www.cdc.gov/drugoverdose/data...