Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Adderall, Nicotine, THC скачать в хорошем качестве

Drugs, Addiction & Neuroplasticity: Psychedelics, MDMA, Opioids, Cocaine, Adderall, Nicotine, THC

About the guest: Robert Malenka, MD, PhD is psychiatrist & neuroscientist. He has spent most of his career at Stanford University, where his lab studies synaptic plasticity, mechanisms of drug action in the brain, and the neural basis of behavior. Episode summary: Nick and Dr. Malenka discuss: mechanisms of synaptic plasticity in the brain, such as LTP & LTD; addiction & the dopamine reward circuitry of the brain; psychoactive drugs ranging from stimulants (cocaine, nicotine, amphetamines) to opioids (fentanyl), psychedelics, MDMA, THC, and alcohol; and more. *This content is never meant to serve as medical advice. All M&M content, including podcast episodes & written content, is available on Substack. I mainly respond to questions & comments on that channel: [ https://mindandmatter.substack.com ] If you enjoy M&M content and want to provide further support, read this: [ https://mindandmatter.substack.com/p/... ] ABOUT Nick Jikomes: Nick is a neuroscientist and podcast host. He is currently Director of Science & Innovation at a technology startup in the legal cannabis industry. He received a Ph.D. in Neuroscience from Harvard University and a B.S. in Genetics from the University of Wisconsin-Madison. #Science #Podcast #Biology #Neuroscience #Psychedelics #Opioids #Nicotine #Cocaine #Adderall #THC #Marijuana #Ketamine #MDMA 0:00:00 Intro 0:02:25 Robert Malenka conversation 00:08:42 Mechanisms of LTP in neurons 00:16:11 Synaptic plasticity mechanisms in the brain 00:27:41 Synaptic plasticity and its role in learning and memory 00:34:08 Neuroplasticity mechanisms and addiction 00:41:28 How drugs of abuse affect dopamine neurons through synaptic plasticity 01:03:12 MDMA's effects on serotonin and dopamine release in mice 01:10:31 Relationship between psychedelic drug effects & therapeutic efficacy 01:22:08 Neurobiology of addiction: gambling, fentanyl, Adderall use in children 01:28:18 Cannabis addiction, synaptic plasticity, and societal problems