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In this episode of This Is Why, we dig into the psychiatric pharmacology of the tricyclic antidepressants (TCA) — not just as legacy antidepressants, but as practical tools for neuropathic pain, migraine prophylaxis, fibromyalgia, IBS-related pain, and insomnia. We’ll connect structure (tertiary vs. secondary amines) to the psychopharmacology of the mechanism, side effects, and real-world choices, then tackle the big safety issue: sodium-channel blockade → QRS widening/QT prolongation, seizures, and what to do in an overdose (including why hypertonic sodium works). 👉 Get free downloads, study tables, playlists, newsletters, and bonus materials for this topic at https://www.thisiswhy.health/topics/p... 👉 Get more with a free membership at https://www.thisiswhy.health/ Access free downloads from our videos Access deep dive content from Dr. Busti Organize content via playlists & collections Join live Q&A Receive member newsletters Coupons & discounts for exam prep resources Chapters 00:00 Introduction to TCAs: Tricyclic Antidepressants 01:45 TCA Modern Indications: Neuropathic Pain, Fibromyalgia, Insomnia & MDD 02:36 TCA Drug Lineup: Tertiary vs Secondary Amines 04:06 Mechanism of Action: Serotonin vs Norepinephrine Reuptake & Structure Differences 05:31 TCA Clinical Uses & Pain Syndromes: IBS, Neuralgia, Migraine Prophylaxis 12:40 Side Effects: Anticholinergic Burden, Sedation, Orthostasis & CNS Toxicity 16:11 Receptor Targets: Histamine, Alpha-1, Muscarinic & Sodium Channel Effects 18:47 Warnings & contraindications (suicidality, MAOIs, cardiac risk) 20:10 Pharmacokinetics & Metabolism: CYP Pathways, Active Metabolites & Drug Interactions 21:06 Drug Interactions (QT Prolongers, serotonergic meds, stimulants) 👍 If this helped you, please like, subscribe, and share it with a classmate or colleague. That will help this new channel continue producing free, high-yield medical education content. 🔔 Don’t forget to turn on notifications so you don’t miss upcoming lectures on diuretics, antihypertensives, antibiotics, and more! #TCAPharmacology #TricyclicAntidepressants #PsychiatryPharmacology #medicaleducation #pharmacologymadeeasy Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard in this content.