Personalized Antihypertensive Therapy - PHYSIC - Dr. Östlund, Prof. Dr. Sundström (Uppsala, Sweden) скачать в хорошем качестве

Personalized Antihypertensive Therapy - PHYSIC - Dr. Östlund, Prof. Dr. Sundström (Uppsala, Sweden)

Prof. Dr. Johan Sundström and Dr. Ollie Östlund discuss personalized therapy in arterial hypertension, focusing upon their landmark PHYSIC study, which compared individual responses to different antihypertensive drugs in uncomplicated hypertension. PHYSIC has been published on 11th April, 2023, in JAMA. Dr. Sundström is Professor at the Department of Medical Sciences, Clinical Epidemiology at Uppsala University, and conjoint professor at the George Institute for Global Health in Sydney. Dr. Östlund is a PhD in mathematics and Expert Statistician in the Biostatistics group at Uppsala Clinical Research Center (UCR), a collaboration between Uppsala University and Uppsala University Hospital. The interview was recorded on May 10th, 2023. Moderators: Prof. Dr. Stephan Schirmer (Kaiserslautern, Germany) and Prof. Dr. Gunnar Heine (Frankfurt, Germany). Articles discussed: Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial. Sundström J, Lind L, Nowrouzi S, Hagström E, Held C, Lytsy P, Neal B, Marttala K, Östlund O. JAMA. 2023 doi: 10.1001/jama.2023.3322. A registry-based randomised trial comparing an SGLT2 inhibitor and metformin as standard treatment of early stage type 2 diabetes (SMARTEST): Rationale, design and protocol. Sundström J, Kristófi R, Östlund O, Bennet L, Eliasson B, Jansson S, Leksell J, Almby K, Lundqvist M, Eriksson JW; SMARTEST study group. J Diabetes Complications. 2021 doi: 10.1016/j.jdiacomp.2021.107996 Monitoring initial response to Angiotensin-converting enzyme inhibitor-based regimens: an individual patient data meta-analysis from randomized, placebo-controlled trials. Bell KJ, Hayen A, Macaskill P, Craig JC, Neal BC, Fox KM, Remme WJ, Asselbergs FW, van Gilst WH, Macmahon S, Remuzzi G, Ruggenenti P, Teo KK, Irwig L. Hypertension. 2010 doi: 10.1161/HYPERTENSIONAHA.110.152421 Chlorthalidone vs. Hydrochlorothiazide for Hypertension-Cardiovascular Events. Ishani A, Cushman WC, Leatherman SM, Lew RA, Woods P, Glassman PA, Taylor AA, Hau C, Klint A, Huang GD, Brophy MT, Fiore LD, Ferguson RE; Diuretic Comparison Project Writing Group. N Engl J Med. 2022 doi: 10.1056/NEJMoa2212270 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Whelton PK, Carey RM, Aronow WS, Casey DE Jr, Collins KJ, Dennison Himmelfarb C, DePalma SM, Gidding S, Jamerson KA, Jones DW, MacLaughlin EJ, Muntner P, Ovbiagele B, Smith SC Jr, Spencer CC, Stafford RS, Taler SJ, Thomas RJ, Williams KA Sr, Williamson JD, Wright JT Jr. Hypertension. 2018 doi: 10.1161/HYP.0000000000000065. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M, Clement DL, Coca A, de Simone G, Dominiczak A, Kahan T, Mahfoud F, Redon J, Ruilope L, Zanchetti A, Kerins M, Kjeldsen SE, Kreutz R, Laurent S, Lip GYH, McManus R, Narkiewicz K, Ruschitzka F, Schmieder RE, Shlyakhto E, Tsioufis C, Aboyans V, Desormais I; ESC Scientific Document Group. Eur Heart J. 2018 doi: 10.1093/eurheartj/ehy339.