A Neuroinflammatory Model for ME/CFS (a hypothesis) скачать в хорошем качестве

A Neuroinflammatory Model for ME/CFS (a hypothesis)

Dr Angus Mackay talks with us about his theory that neuroinflammation is the cause of ME/CFS (and Long Covid related post-viral fatigue syndrome). Presentation for MECFS Canterbury, 14th February 2024. Angus hopes that as brain imaging techniques develop, the model will be used by researchers to explore and develop a better understanding of this debilitating disease. The model revolves around a dysfunctional and inflamed hypothalamus, the master gland within the brain, and the stress-response centre within it, called the paraventricular nucleus (PVN), that responds to all significant stressors including viral and other shocks. ____________________________ ADDITIONAL RESOURCES: ✦ Timestamped slide list further below ✦ Pdf of the slide deck - https://drive.google.com/file/d/1Hxjj... ✦ Biography and Outline of presentation https://drive.google.com/file/d/1QNyO... ✦ The published papers on the theory: Mackay, A. (2021). A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS. Frontiers in neurology, 12, 701419-701419. https://doi.org/10.3389/fneur.2021.70... Mackay, A. (2019). A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis/chronic fatigue syndrome. Journal of primary health care, 11(4), 300-307. https://doi.org/10.1071/HC19041 Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International journal of immunopathology and pharmacology, 32, 205873841881234. https://doi.org/10.1177/2058738418812342 ____________________________ CONTENT /SLIDE LIST: 00:00 Introduction . 02:54 An analogy of ME/CFS - the two jars . 05:31 Presentation topic: A Neuroinflammatory Model for ME/CFS 06:02 A Personal Journey – Gaining insight into ME/CFS . 08:46 Why has Neuroinflammatory Hypothesis for ME/CFS been slow to take off? Neuorinflammation in ME/CFS brains chronic but at a low-level Brain does not contain nociceptors (pain/ heat receptors) The red herrings 15:57 The Hypothalamus (master gland) is Key 18:55 Hypothalamic Paraventricular Nucleus (PVN) - Eureka!! 20:38 Possible Triggering Mechanism of ME/CFS 23:20 Glial-cells (brain /Central Nervous System immune cells) 27:01 Increasing Evidence of Neuroinflammation in ME/CFS 32:48 ME/CFS Symptoms (Explanation of) 36:04 PEM (Post-exertional malaise), Flares and Relapses 42:21 Stressors and Paraventricular Nucleus (PVN) 45:16 PVN is same target for Triggering Stressors and Perpetuating Stressors of ME/CFS . 45:49 A Neuroinflammatory Model for ME/CFS . 49:59 The Long COVID Conundrum 52:30 Possible triggering mechanism for Long-COVID related ME/CFS 53:39 Evidence of Neuroinflammation in Long-COVID 54:29 Further Evidence of Neuroinflammation in Long-COVID (ME/CFS) 55:30 A Neuroinflammatory Model for ME/CFS applicable to Long-COVID related ME/CFS . 55:56 Future Needs 1:00:53 Pacing How to Pace Yourself with ME/CFS (or Fibromyalgia or Long-COVID related ME/CFS) Avoid unnecessary stressors Listen to your body Manage your symptoms . 1:03:04 The Papers Related to this Model Mackay, A. (2021). A Paradigm for Post-Covid-19 Fatigue Syndrome Analogous to ME/CFS. Frontiers in neurology, 12, 701419-701419. https://doi.org/10.3389/fneur.2021.70... Mackay, A. (2019). A neuro-inflammatory model can explain the onset, symptoms and flare-ups of myalgic encephalomyelitis/chronic fatigue syndrome. Journal of primary health care, 11(4), 300-307. https://doi.org/10.1071/HC19041 Mackay, A., & Tate, W. P. (2018). A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS. International journal of immunopathology and pharmacology, 32, 205873841881234. https://doi.org/10.1177/2058738418812342 . 1:03:44 Questions 1:03:59 Is it a genetic susceptibility or does this susceptibility change over time? As many people report coping with many stressors, and then something similar happens that then triggers ME/CFS. 1:06:40 Example shared of a recent relapse caused by exposure to more sunlight when blinds were removed for cleaning. 1:08:27 Angus’s connection dropped out 1:08:33 How did people find the talk? 1:10:10 Angus returns 1:10:30 Does this model resonate with people? Eye pain; feeling of a swollen head. 1:13:35 Thank you Angus 1:15:18 We need researchers to explore and validate the model now . 1:16:42 Thank you to the funders of MECFS Canterbury