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Can “blood filtration” act like an oil change for chronic inflammation? In this episode, Dr. Mobeen Syed, also known as Dr. Been, returns to discuss a hot topic in chronic inflammation and spike-related syndromes: therapeutic plasma exchange (TPE) and other blood filtration approaches. We break down what these procedures actually do, what they can remove from circulation, and why that might matter for brain fog, fatigue, microvascular dysfunction, and neuroinflammation. Dr. Been outlines the core methods: classic plasma exchange, immunoadsorption, and other extracorporeal options. We discuss the proposed “reset” effect, including reducing inflammatory mediators, autoantibodies, and abnormal clotting signals that may keep the body stuck in a vicious cycle. We review a sham-controlled randomized trial that found TPE to be safe but ineffective in that cohort, and discuss why a single intervention may help only a subset, if at all. If you want a clear, mechanism-first explanation without the hype, this conversation is for you. Share it with someone experiencing brain fog or fatigue, and subscribe for more evidence-based brain health deep dives. “Normally, the body is very efficient in removing extraneous harmful substances. When the body is unable to remove them because they are difficult to remove (like beta-pleated fiber sheets) and they are being produced a lot, we need to give the body a break. So we clean out the plasma.” ~ Dr. Mobeen Syed, MD, MSc In this Episode 00:00 - Introduction to Dr. Mobeen Syed, MD, MSc 02:51 - Dr. Been's opinion on the benefits of TPE 04:37 - Can we remove bad things from the blood? 11:18 - The core idea: dislodge first, filter after 23:40 - What the studies say about TPE 49:16 - Can TPE reverse the effects of chronic inflammation and spike protein? 53:33 - Clarification of concepts and terminologies discussed 1:01:52 - Key takeaway from today's episode Resources: Top Supplements for Alzheimer's Guide - https://bit.ly/drjoshguide Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease - https://www.mdpi.com/2218-273X/15/7/1000 Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin - https://pmc.ncbi.nlm.nih.gov/articles... Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms - https://pubmed.ncbi.nlm.nih.gov/33880... Connect with Dr. Mobeen Syed, MD, MSc: Website - https://members.drbeen.com/courses YouTube - / @drbeenmedicallectures Connect with Dr. Josh Helman, MD: Instagram - / greenbrainsmd Facebook - / greenbrainsmd LinkedIn - / doctorjosh TikTok - / greenbrainsmd YouTube - / @greenbrainsmd Others - https://linktr.ee/greenbrainsmd Disclaimer: Please remember that this podcast is for informational purposes only and is not intended as medical advice. Always consult your doctor or healthcare professional before making any changes to your treatment plan. #TherapeuticPlasmaExchange #SpikeProtein #BrainFog