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(Bethesda, MD) In this presentation, Mary Hardy, M.D., who board certified in internal medicine and a specialist in botanical and integrative medicine, explains the concept of safety and how it is defined, measured, studied, and reported with regard to dietary supplements. She provides examples to illustrate the ways in which the safety of various supplement ingredients has been evaluated. This presentation also includes a discussion of the patchwork of systems in place to monitor for adverse effects of supplements and how safety concerns vary by population subgroups. This presentation is part of the 2018 Mary Frances Picciano Dietary Supplement Research Practicum sponsored by the NIH Office of Dietary Supplements (ODS). This 2.5-day annual event for faculty, students, and health practitioners provides a thorough overview of issues, concepts, unknowns, and controversies about dietary supplements and supplement ingredients. It also emphasizes the importance of scientific investigations to evaluate the efficacy, safety, and value of these products for health promotion and disease prevention as well as how to carry out this type of research. For more information: https://ods.od.nih.gov/Research/dsrp....