The technology is here today to reprogram your cells - Dr. Janine & Rob (Junevity) скачать в хорошем качестве

The technology is here today to reprogram your cells - Dr. Janine & Rob (Junevity)

Dr. Janine Sengstack and Rob Cahill, founders of the startup Junevity, are on a mission to extend lifespan and healthspan by combining AI and large scale omics data with genetic medicines known as “siRNAs”. Their cellular reset platform promises to create medicines that can reset each of your organs back to a healthy and youthful state. This year, Junevity successfully restored "18-year-old metabolism" in animal models allowing mice on a high-fat diet to lose fat while retaining muscle. This candidate therapy may become the first known drug to rejuvenate metabolism. Since our recording, Junevity doubled their seed round funding up to $20M to advance this work into human clinical trials, which means we might see their first rejuvenating medicine in the clinic as soon as the second half of next year. You may have noticed that this episode was recored in a super cool podcasting studio! Special thank you to Omri Amirav-Drory and the NFX (www.nfx.com) team for generously lending us their podcasting studio! 0:00 Intro 2:29 Junevity’s Cell Reset Platform 3:57 The science behind the platform 8:34 Rob’s transition from exited tech founder to biology student 12:59 What makes for good co-founder relationships 16:12 Why right now is the moment for longevity biotech 18:05 Black box AI vs traditional biology 23:21 Advantages of siRNAs for cell reset 32:32 Junevity’s secret sauce 36:09 The primary challenge in all preclinical work today 40:16 siRNAs for obesity 49:04 Timing for achieving longevity escape velocity 55:26 The Ozempic or ChatGPT moment for longevity 1:02:54 Bottlenecks to accelerating longevity 1:07:31 What’s next for Junevity