Cephalosporins: Generation 1 (Stronger than you think) – Cefazolin, Cephalexin (NEET SS, MRCP) скачать в хорошем качестве

Cephalosporins: Generation 1 (Stronger than you think) – Cefazolin, Cephalexin (NEET SS, MRCP)

Welcome to Medicine Beyond Harrison. In the era of broad-spectrum abuse, the First Generation Cephalosporins—Cefazolin and Cephalexin—are the unsung heroes of Antimicrobial Stewardship. In this lecture, we move beyond the basic "Gram-positive coverage" definition. We dissect why Cefazolin is often superior to anti-staphylococcal penicillins (like Nafcillin) for MSSA bacteremia, debunk the "10% cross-reactivity" myth regarding penicillin allergies, and provide concrete dosing strategies for obesity and renal failure. 📝 Topics Covered in This Video: The Big Picture: Why G1 Cephalosporins are the backbone of stewardship for SSTI and MSSA. Pharmacology: Mechanism of action, PK/PD targets (Time more than MIC), and tissue penetration. The Penicillin Allergy Myth: Understanding R1 side chains and why Cefazolin is safe in most penicillin-allergic patients. Cefazolin vs. Nafcillin: Why Cefazolin is the drug of choice for MSSA (less nephrotoxicity, better tolerability). Clinical Dosing: Standard dosing vs. High-dose (2g q8h) for Endocarditis/Bacteremia vs. Obesity dosing. IV to Oral Switch: The "Handover" strategy using Cephalexin (Bioavailability and PEPT1 transport). Spectrum: What it covers (MSSA, Strep, P. mirabilis) and what it misses (Enterococcus, MRSA, Pseudomonas). Question: You have a patient with MSSA Bacteremia. They have a history of "anaphylaxis to Penicillin." Can you use Cefazolin? Answer: YES. (With rare exceptions). Cefazolin has a unique R1 side chain that does not cross-react with other beta-lactams. The old "10% cross-reactivity" rule is based on contaminated drug supplies from the 1970s. References & Further Reading Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (9th Ed). Harrison's Principles of Internal Medicine, 21st Ed. Li et al. "Beta-lactam antibiotic cross-reactivity: A review and update." Mayo Clinic Proceedings. IDSA Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections. UpToDate: "Cephalosporins" and "Choice of antibiotics in penicillin-allergic hospitalized patients." First Generation Cephalosporins, Cefazolin dosing renal failure, Cephalexin dosage for cellulitis, Cefazolin vs Nafcillin MSSA bacteremia, Penicillin allergy cephalosporin cross reactivity, Antibiotic Stewardship, Medicine Beyond Harrison, NEET SS General Medicine, MRCP Infectious Disease, Pharmacology for Physicians, Beta Lactam antibiotics mechanism of action, Keflex dosing, Ancef dosing obesity, Treatment of MSSA bacteremia, Surgical Prophylaxis antibiotics. Primary: First Generation Cephalosporins, Cefazolin, Cephalexin, Antibiotic Stewardship, MSSA Treatment. Secondary: Penicillin Allergy Cross Reactivity, Beta Lactam Antibiotics, Infectious Disease Pharmacology, Cellulitis Treatment, Endocarditis Treatment. Exam Specific: NEET SS Medicine, MRCP Part 1, USMLE Step 2 CK, ABIM Infectious Disease. #Cefazolin #Cephalexin #InfectiousDiseases #AntibioticStewardship #MedEd #MedicineBeyondHarrison #InternalMedicine #Pharmacology #NEETSS #MRCP #Doctors #MedicalResidency