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implemented daily 16-hour fasting for 6 months. Initially it worked - then complete plateau. Fat loss stalled, energy crashed, sleep got worse. I'm David Sinclair, a genetics professor at Harvard Medical School. I discovered why daily fasting stops working - and the strategic protocol that doubled my fat loss. Scientists compared 12hr, 16hr, 24hr, and 36hr fasting windows. One melted fat so aggressively it shocked researchers. MY RESULTS (12 WEEKS): Lost 14.2 lbs pure fat (DEXA verified) Gained 1.8 lbs lean muscle Insulin sensitivity improved 56% Waist: 34" → 31.5" (-2.5") THE PROBLEM WITH DAILY FASTING: Daily 16hr fasting = chronic caloric restriction → your metabolism adapts → you plateau. THE SOLUTION: Strategic 36-hour fast ONCE per week + proper refeeding on other days = metabolic contrast that prevents adaptation. THREE PROTOCOL OPTIONS: Advanced: 36hr fast weekly Intermediate: 24hr fast weekly Beginner: 16hr fast 4X weekly + refeed day Disclaimer: This is a fan-made channel, and its content is not affiliated with David Sinclair or his companies. The videos are inspired by David Sinclair's public statements and ideas for educational and motivational purposes only, using a synthesized voice that does not belong to David Sinclair. We use visual lip-syncing and dubbed narration to match the spoken words with on-screen footage, purely to enhance clarity, create a cinematic experience, and make the content more engaging for viewers. Our aim is to amplify the original message by making it easier to understand for the end consumer, helping us reach and educate more people with David Sinclair's valuable perspectives. We also make the messages of David Sinclair more accessible to people who are deaf or hard of hearing by applying professional transcription to the majority of our videos. We share his visionary ideas in a respectful and inspiring manner, without any intent to mislead. Our channel’s content is based on facts, rumors, and fiction. Nothing on this channel is nutrition or medical advice. 🔥 Daily 16hr fasting long-term = chronic caloric restriction = metabolic adaptation = plateau 🔥 Scientists compared 12hr, 16hr, 24hr, 36hr windows - 36hr produced most dramatic fat loss when cycled strategically 🔥 Three biggest mistakes: Chronic fasting without refeeding, inadequate protein, no metabolic cycling 🔥 Three key principles: Fasting = hormetic stress, protein restores anabolic capacity, overfasting backfires 🔥 Three protocol options: Advanced (36hr weekly), Intermediate (24hr weekly), Beginner (16hr 4X weekly with refeed) 🔥 Five avatars: Personalized protocols based on experience level, stress, body composition, age 🔥 Five red flags: Cold hands, poor sleep, strength loss, irritability, paradoxical belly fat gain 🔥 Mineral strategy critical: Fulvic/humic acids during fasts (doesn't break fast, prevents weakness/dizziness) 🔥 My results (12 weeks): -14.2 lbs fat, -56% HOMA-IR, ketones 2.4-2.8 mmol/L, +1.8 lbs lean mass maintained 🔥 Timeline: Weeks 1-2 adaptation, weeks 2-4 substantial loss, weeks 4-8 continued progress, weeks 8-12 new baseline 🔥 Fundamental principle: Fat loss requires metabolic contrast, not constant deprivation Within 12 weeks: I lost 14.2 pounds of fat (primarily visceral), improved insulin sensitivity by 56%, established metabolic flexibility - from understanding metabolic biology and implementing strategic contrast (36hr fast + proper refeeding), not constant deprivation. This is Dr. David Sinclair from Harvard Medical School. Your metabolism can be optimized for sustained fat loss - you just need the right protocol. 👍 LIKE if you're implementing strategic fasting 🔔 SUBSCRIBE for evidence-based metabolic optimization 📤 SHARE with someone stuck on daily 16hr fasting plateau ⚠️ DISCLAIMER: Educational purposes only. Not medical advice. Consult healthcare provider before implementing fasting protocols, especially if you have medical conditions, take medications, or have history of eating disorders. Individual results vary. 🏷️ TAGS David Sinclair, fasting, intermittent fasting, 36 hour fast, 16 hour fast, fat loss, metabolic adaptation, autophagy, ketosis, growth hormone, insulin sensitivity, HOMA-IR, metabolic flexibility, cortisol, thyroid, protein, refeeding, Harvard research, weight loss plateau, hormetic stress, AMPK, body composition #️⃣ HASHTAGS #DavidSinclair #Fasting #IntermittentFasting #36HourFast #16HourFast #FatLoss #MetabolicAdaptation #Autophagy #Ketosis #GrowthHormone #InsulinSensitivity #MetabolicFlexibility #Cortisol #Thyroid #Refeeding #HarvardResearch #WeightLossPlateau #HormeticStress #AMPK #BodyComposition #Biohacking