G-Protein Coupled Receptors (GPCRs) & Second Messenger Systems | Pharmacology скачать в хорошем качестве

G-Protein Coupled Receptors (GPCRs) & Second Messenger Systems | Pharmacology

Watch next - Introduction to pharmacokinetics:    • Introduction to Pharmacokinetics: ADME Ove...   If you'd like to support EKG Science 💙 PayPal - https://www.paypal.com/paypalme/ekgsc... --- In this lecture EKG is going to cover G protein-coupled receptors (GPCRs) and second messengers. We’re going to break down the structure of GPCRs and G proteins and how the binding of an agonist drug leads to the activation of that G protein. Then we’ll explore what second messengers are, looking at the phospholipase C/inositol phosphate second messenger system as well as the second messenger’s cyclic amp and cyclic GMP, and we’ll also go through examples of drugs that interfere with these different processes. Table of Contents: 0:00 Intro 0:36 Structure of GPCRs & G Proteins 6:25 Activation of GPCRs & G Proteins 11:27 Second Messengers 15:57 Phospholipase C/Inositol Phosphate Pathway 24:48 Cyclic Nucleotides (cGMP & cAMP) 33:06 Adenylyl Cyclase & cAMP Pathway For educational purposes only; NOT medical or other advice. Lecture Source: Ritter, J., Flower, R.J., Henderson, G., Yoon Kong Loke and Rang, H.P. (2018). Rang and Dale’s Pharmacology. 9th ed. Endinburgh: Elsevier. #pharmacodynamics #pharmacology #ekgscience