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What really happens after 36 hours with no food? In this powerful 25:57 deep dive, Dr. Josh Axe breaks down the brand-new science behind extended water fasting and what it does to your metabolism, brain, hormones, fat-burning pathways, and cellular repair systems. By the 36-hour mark, your body shifts dramatically. Insulin drops. Ketones rise. Growth hormone increases. Autophagy activates. Inflammation markers may decrease. But is this metabolic breakthrough safe? And who should actually try it? In this episode, you’ll discover: • The exact metabolic timeline from hour 0 to hour 36 • When fat burning truly accelerates • What happens to your brain on ketones • How autophagy supports cellular cleanup • The truth about muscle loss during fasting • Electrolyte mistakes that sabotage results • Who should avoid extended fasting • The right way to break a 36-hour fast If you want to improve insulin sensitivity, support metabolic flexibility, reduce inflammation, and understand the science behind water fasting — this is your complete guide. Watch until the end to learn whether a 36-hour fast is a powerful reset… or just another misunderstood health trend. ⏱️ TIMESTAMPS: 00:00 – What Happens After 36 Hours Without Food? 02:12 – The 12-Hour Metabolic Shift 04:38 – Glycogen Depletion & Fat Burning Begins 06:55 – Ketones Explained 09:21 – Growth Hormone & Metabolic Boost 11:40 – Autophagy Activation 14:03 – Brain Function on Ketones 16:22 – Hunger Hormones & Appetite Control 18:47 – Inflammation & Immune Effects 21:05 – Who Should NOT Fast 23:18 – How to Break a 36-Hour Fast Properly 25:10 – Is This a Metabolic Breakthrough? Tags: 36 hour fast, water fasting, extended fasting, autophagy benefits, fat burning science, ketosis explained, insulin resistance, metabolic flexibility, intermittent fasting, growth hormone fasting, cellular repair, inflammation reduction, fasting for weight loss, brain health fasting, new fasting study, insulin sensitivity, visceral fat loss, keto metabolism, health podcast, natural health doctor, hormone optimization, immune system reset, mitochondrial health, fasting tips, electrolyte balance, fasting mistakes, metabolic reset, anti aging fasting, doctor josh axe, healthy lifestyle, Hashtags: #36HourFast, #WaterFasting, #Autophagy, #FatBurning, #Ketosis, #IntermittentFasting, #InsulinResistance, #MetabolicHealth, #GrowthHormone, #CellularRepair, #Inflammation, #BrainHealth, #FastingScience, #Longevity, #Mitochondria, #HormoneHealth, #VisceralFat, #Wellness, #NaturalHealth, #HealthyLiving, #ImmuneSupport, #AntiAging, #KetoLife, #FastingTips, #HolisticHealth, #MetabolicReset, #NutritionScience, #Biohacking, #HealthEducation, #DrJoshAxe, Keywords: water fasting benefits, 36 hour fasting results, what happens after 36 hours fasting, new fasting research, extended fasting science, autophagy human study, ketosis timeline, insulin drop fasting, fasting for inflammation, fasting brain clarity, growth hormone increase fasting, fasting and fat loss, fasting and metabolism, fasting and immune system, fasting and longevity, how to do 36 hour fast, fasting electrolyte guide, fasting for insulin sensitivity, visceral fat fasting, metabolic switch fasting, mtor and autophagy, ketones for brain health, fasting hormone balance, intermittent vs extended fasting, safe water fasting tips, fasting for cellular repair, 24 vs 36 hour fast, natural fat burning methods, fasting transformation, metabolic health optimization,