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Is obesity a failure of willpower — or a chronic disease? In this episode of *Overheard in the Emergency Room*, Emergency Physician Dr. Adrian Cois explains the science of obesity using real emergency department cases, clinical guidelines, and the latest research. You’ll learn: • Why body weight is biologically regulated by the brain • How hormones like leptin, ghrelin, insulin, and cortisol influence weight • Why the body fights back against weight loss • The evidence behind GLP‑1 medications like semaglutide and tirzepatide • What bariatric surgery research shows about long‑term survival • How weight stigma in healthcare worsens outcomes • How to spot misinformation from wellness influencers This episode walks through the evidence behind modern obesity treatment using a two‑tier framework: Tier 1: Lifestyle interventions (nutrition, exercise, sleep, stress regulation) Tier 2: Pharmacotherapy and bariatric surgery We also review landmark trials including: STEP‑1 (Semaglutide) SURMOUNT‑1 (Tirzepatide) Swedish Obese Subjects Study (Bariatric surgery) Obesity is not a character flaw. It is a complex neurohormonal disease influenced by genetics, environment, and biology. Understanding the science is the first step toward treating it. Visit DrCois.com for free health resources. 👍 Like the video 🔔 Subscribe for future episodes 💬 Comment with your thoughts or questions