Ben Roberts | An Engine Without A Machine скачать в хорошем качестве

Ben Roberts | An Engine Without A Machine

Apply to join Foresight Molecular Machines program: https://foresight.org/molecular-machi... A group of scientists, entrepreneurs, and institutional allies who cooperate to advance molecular machines, applications in energy, medicine, and material science, and long-term progress toward Richard Feynman’s vision of nanotechnology. Ben Roberts | An Engine Without A Machine: Using An Information Ratchet To Improve Selectivity In Dna Duplex Formation Ben is a postdoc in the Prins group at the University of Padua, working on nonequilibrium chemical systems. He obtained his PhD in the Leigh group at the University of Manchester working on designing and understanding autonomous chemically fuelled molecular motors and pumps. https://x.com/benjamino_acid Abstract: The consumption of chemical energy to drive the formation of complex, out-of-equilibrium structures is a key tool used by biological organisms to achieve the high-fidelity recognition and responsive structures necessary for life. However, while recent advances in (single-component) molecular motors and pumps have provided insight into this chemistry, the problem of how to achieve such behaviors in multi-component reaction systems has proven far from trivial. Using competitive DNA duplex formation for a model system, we have created an information ratchet that demonstrates that a higher selectivity can be achieved using an energy dissipating process than through the use of thermodynamic recognition elements alone. This mirrors kinetic proofreading in biological systems, though without relying on complex cellular machinery. Indeed, we demonstrate that, like kinetic proofreading during DNA replication or protein synthesis, our ratchet increases the quantity of information transferred from the template to the duplex identity, potentially indicating a solution to Eigen’s paradox by lowering the complexity threshold required to achieve super-statistical selectivity. Timecodes 00:00 Introduction and Welcome 00:30 Overview of Molecular Machines 03:01 Challenges at the Molecular Scale 05:25 Designing a Molecular Motor 08:48 Mechanism of Directional Rotation 17:34 DNA-Based Information Ratchet 37:36 Q&A Session ══════════════════════════════════════ About The Foresight Institute The Foresight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1986 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support. From molecular nanotechnology, to brain-computer interfaces, space exploration, cryptocommerce, and AI, Foresight gathers leading minds to advance research and accelerate progress toward flourishing futures. We are entirely funded by your donations. If you enjoy what we do please consider donating through our donation page: https://foresight.org/donate/ Visit https://foresight.org, subscribe to our channel for more videos or join us here: • Twitter:   / foresightinst   • Facebook:   / foresightinst   • LinkedIn:   / foresight-institute