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Perimenopause can feel like your body and emotions have suddenly turned against you. In this episode of Peptides and Longevity, Dr. Jen Pfleghaar explains why progesterone declines first, why estrogen becomes erratic, and how stress, toxins, and insulin resistance can drive anxiety, weight gain, libido changes, and skin issues years before menopause. Follow Us On Social Media: IG: /holtorfmedicalgroup FB: /holtorfmed ---- Connect with Dr. Jen: Website: pflegmed.com/dr-jen Instagram: instagram.com/integrativedrmom LinkedIn: linkedin.com/in/drjenpfleghaar/ Three Takeaways ✅ Discover why progesterone often declines years before menopause and how that early shift can trigger anxiety, mood changes, and estrogen-dominant symptoms. ✅ Understand why 'normal' hormone labs can miss the real drivers when cortisol, insulin resistance, mold exposure, and blood sugar dysregulation are involved. ✅ Learn why supporting hormones requires a low-and-slow, individualized approach that also protects muscle, metabolism, intimacy, and long-term health. About the Guest Dr. Jen Pfleghaar is a physician specializing in women’s hormones, thyroid health, and the complex transition of perimenopause. She focuses on identifying why symptoms like anxiety, weight gain, mood changes, low libido, and skin issues often appear years before menopause and why they are frequently overlooked or misattributed. Dr. Jen emphasizes comprehensive testing, careful hormone balance, and addressing underlying drivers. She integrates lifestyle foundations with targeted hormone and peptide strategies to support metabolism, muscle health, intimacy, and long-term vitality throughout the perimenopause transition. #Peptides #longevity #holtorfmedicalgroup