Advancing best practices in Dose Selection for DART Studies скачать в хорошем качестве

Advancing best practices in Dose Selection for DART Studies

Current ECHA guidance on dose selection to test the toxicity of a chemical in developmental and reproductive toxicology (DART) studies has come under scrutiny for causing unnecessary suffering to animals as well as potential secondary effects that could obscure relevant reproductive outcomes. Since 2019, the ECETOC Dose Selection Task Force (https://www.ecetoc.org/task-force/dos...) has been advancing best practices in dose-setting for toxicity studies. In 2024, they published their latest recommendations (https://www.ecetoc.org/publication/do..., building on earlier work (https://www.ecetoc.org/publication/tr... This webinar explores critical insights, including how the team integrated regulatory guidance, animal welfare considerations, and cutting-edge science and reflects on key dialogues since the publication, like the 2024 EUROTOX satellite event on DART dose selection (https://www.ecetoc.org/wp-content/upl..., outlining next steps for progress in this vital field.