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Welcome to Week 7 Lecture 7 Part 1 of the course "Big Data and Biological Networks" by Dr. Nirav P Bhatt , Karthik Raman , Prof. Himanshu Sinha. Full Course: https://study.iitm.ac.in/ds/course_pa... Video Overview In this lecture, we introduce the fundamentals of genome assembly and understand why it plays a crucial role in modern biology and genomics. The video discusses how raw sequencing reads are processed and combined to reconstruct entire genomes. We explore the major challenges in genome assembly such as repetitive regions, read errors, and sequencing limitations that complicate accurate reconstruction. The concept of k-mers is explained in detail, including how they are generated from sequences and how they support assembly algorithms by breaking sequences into overlapping fragments. This lecture sets the foundation for advanced genome assembly strategies that will be covered in upcoming videos. For more details, visit: https://study.iitm.ac.in/ds/course_pa... Dr Himanshu Sinha Professor, Department of BioTechnology, Bhupat and Jyoti Mehta School of Biosciences Indian Institute of Technology Madras Lab homepage: https://home.iitm.ac.in/sinha/ GitHub: https://github.com/HimanshuLab About IIT Madras' online Bachelor of Science programme IIT Madras offers four year BS programmes that aim to provide quality education to all, irrespective of age, educational background, or location. The BS programme has multiple levels, which provide flexibility to students to exit at any of these levels. Depending on the courses completed and credits earned, the learner can receive a Foundation Certificate from IITM CODE (Centre for Outreach and Digital Education), Diploma(s) from IIT Madras, or BSc/BS Degrees from IIT Madras. For more details, Visit: https://www.iitm.ac.in/academics/stud... #GenomeAssembly #Bioinformatics #BigDataAndBiology #BiologicalNetworks #KMers #Genomics #IITMadras #BSProgramme #DataScienceAI