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Migraine Medications

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this neuropharmacology lecture, Professor Zach Murphy presents a focused breakdown of Migraine Medications, helping you master the acute and preventive treatment strategies for one of the most common and debilitating neurological disorders. This lecture ties together the underlying pathophysiology of migraines with the mechanism of action of key pharmacologic agents. We begin by reviewing the phases of a migraine and the role of trigeminovascular activation, neurogenic inflammation, and serotonin (5-HT) pathways. From there, we cover first-line abortive therapies such as triptans, NSAIDs, and ergot alkaloids, emphasizing how they work to suppress vasodilation and neuropeptide release during an acute attack. The lecture then transitions into preventive therapies, including beta blockers (propranolol), anticonvulsants (topiramate, valproate), tricyclic antidepressants (amitriptyline), and CGPR monoclonal antibodies like erenumab. You’ll learn to select medications based on comorbidities, side effect profiles, and patient-specific factors. Enjoy the lecture and support us below! Table of Contents: 0:00 Lab 0:29 Pathophysiology of Migraines 13:02 Mechanism of Action and Migraine Medication Names 27:19 Adverse Effects and Contraindications 40:54 Comment, Like, SUBSCRIBE! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #migraine #migrainemedications