KS Insights: Neurodegenerative Diseases: New Insights and Therapeutic Opportunities скачать в хорошем качестве

KS Insights: Neurodegenerative Diseases: New Insights and Therapeutic Opportunities

About Keystone Symposia Insights Keystone Symposia Insights are panel discussions recorded on digital video that feature Keystone Symposia meeting organizers discussing the state of their respective fields. These thought leaders provide perspectives on current and future trends. The panel is asked to discuss the following topics: What is the state of this field? (What did we learn at the meeting?) Where is the field heading? What are the opportunities and challenges ahead? ___ Keystone Symposia Conference: Neurodegenerative Diseases: New Insights and Therapeutic Opportunities Organizer(s) Valina L. Dawson, Joseph W. Lewcock and Fred H. Gage June 16—20, 2019 Keystone Resort • Keystone, Colorado USA Sponsored by BioLegend, Inc., Biogen, BlueRock Therapeutics, Genentech, Inc., Ionis Pharmaceuticals, Inc., Roche and Takeda Pharmaceutical Company Limited The global burden of neurodegenerative disease is staggering and growing at an alarming rate as the population ages. While Alzheimer’s disease and related dementias, as well as, Parkinson’s disease and related disorders, account for the majority of those afflicted, there are also less common but equally devastating diseases. Technical and conceptual advances are revealing disease mechanisms and providing new therapeutic opportunities. Misfolded proteins have been understood to be at the center of neurodegenerative diseases but recently there is an appreciation that these misfolded proteins may serve as seeds to template the misfolding of normal proteins, that transmission of these seeds may underlie disease progression, and that there may be different strains of these seeds with differential toxicities. Biophysical analysis of these proteins reveals a role for phase transition and liquid demixing of these intrinsically disordered proteins. Synaptic loss is an important feature of neurodegeneration which may occur long before neuronal loss, but be critically important in disease presentation and loss of function. Glia and immune activation contribute to neurodegeneration and synaptic loss, and must be understood and controlled if the disease process is to be tempered or stopped. This conference aims to address the current state of knowledge in these emerging area and to provide advanced discussion of these topics; the opportunity for interaction between scientists from different fields of research will foster new collaborations that may lead to new therapeutic opportunities to combat the coming crisis and provide medical care for those suffering from neurodegenerative diseases. ___ Copyright Keystone Symposia, 2019. All rights reserved. About Keystone Symposia: Keystone Symposia is a 501(c)(3) nonprofit organization founded in 1972 that convenes 50-60 open, international scientific research conferences each year across the full range of the life sciences – from cardiovascular disease to immunology to neurobiology. The conferences accelerate life science discovery by bringing together and fostering collaboration among the world’s leading and next generation of research scientists. Visit Keystone Symposia at: https://www.keystonesymposia.org Visit Virtual Keystone Symposia at: https://virtual.keystonesymposia.org/ For more videos:    / keystonesymposia   Follow us on Twitter:   / keystonesymp   Like us on Facebook:   / keystonesymposia   Link to us on LinkedIn: https://www.linkedin.com/company/1279...