Sickle Cell Anemia Explained | Pathogenesis, Peripheral Smear, Radiology & Dental Considerations скачать в хорошем качестве

Sickle Cell Anemia Explained | Pathogenesis, Peripheral Smear, Radiology & Dental Considerations

#SickleCellAnemia #OralPathology #DentalStudents In this video, we walk through sickle cell anemia using a clinical case-based approach to make the disease easier to understand and remember. The discussion starts with a 23-year-old patient presenting with abdominal pain, chest pain, anemia, jaundice, recurrent infections, and a shrunken spleen, and gradually connects every clinical, hematological, radiological, and dental finding into one coherent picture. You will understand why sickle-shaped red blood cells form, how a single genetic mutation in the beta globin chain leads to hemoglobin S, and how repeated sickling causes chronic hemolytic anemia and microvascular occlusion. The video explains key peripheral smear findings such as sickle cells, target cells, Howell–Jolly bodies, reticulocytes, and nucleated RBCs, along with their clinical significance. Systemic complications including autosplenectomy, gallstones, acute chest syndrome, vaso-occlusive crises, stroke, and chronic leg ulcers are explained in a logical flow. Special emphasis is given to jawbone and dental radiographic findings such as step ladder trabeculation, thinning of mandibular cortex, healed infarcts, and hair-on-end appearance of the skull. The video also covers oral manifestations, dental management protocols, antibiotic prophylaxis, anesthesia considerations, and preventive dental care in patients with sickle cell disease. Associated syndromes like hand-foot syndrome, acute chest syndrome, and sequestration syndrome are discussed, along with treatment options including blood transfusion, hydroxyurea therapy, vaccination, and bone marrow transplantation. This video is especially useful for BDS students, oral pathology revision, NEET MDS preparation, and understanding systemic diseases with oral relevance. Timestamps 00:00 Case introduction and presenting symptoms 00:54 Imaging findings and clinical suspicion 01:33 Blood investigations and reticulocyte count 02:18 Peripheral smear findings explained 03:00 Howell–Jolly bodies and splenic pathology 03:42 Confirmation of sickle cell anemia 04:28 Normal hemoglobin types and genetics 05:12 Mutation in beta globin chain 05:54 Sickling mechanism and reversibility 06:33 Hemolytic anemia and bilirubin metabolism 07:12 Bone marrow changes and radiographic signs 08:16 Vaso-occlusive crisis explained 08:55 Autosplenectomy and infection risk 09:37 Oral manifestations of sickle cell disease 10:16 Jawbone radiographic features 10:52 Dental management principles 11:29 Antibiotic prophylaxis and anesthesia considerations 12:10 Associated syndromes overview 12:48 Acute chest syndrome and mortality 13:26 Sickle cell trait vs disease 14:05 Treatment options and prognosis 14:38 Malaria protection and epidemiology Useful Links: Our website: https://www.medistudygo.com/ Instagram:   / medi_study_go   Our Telegram Channel (Free Mindmaps and more): https://t.me/MediStudyGoTG Our app: https://play.google.com/store/apps/de... 🌐 Website: www.medistudygo.com 🛒 Also available on Amazon, Flipkart & Dentalkart https://www.amazon.in/stores/page/2D8... Follow us for daily dental & medical study content: 🦷 Dental Instagram:   / medi_study_go   🩺 Medical Instagram:   / medi_study_go_medical   💬 Telegram: https://t.me/MediStudyGoTG 💼 LinkedIn:   / medi-study-go   📌 Pinterest: https://pin.it/qEdS6pug3 📱 Download the MediStudyGo App: Android (Play Store): https://play.google.com/store/apps/de... iOS (App Store): https://apps.apple.com/us/app/medi-st... Contact us for any queries or support 📧 Email: support@medistydygo.com 📱 WhatsApp: +91 7483891504 Join our WhatsApp Students Community 👇 🔗 https://chat.whatsapp.com/KW27WrOKbXD... #Hematology #OralMedicine #BDSFinalYear #NEETMDS #MedicalDentistry #SystemicDiseases