Vitamin D & Implant Failures: The Hidden Variable Surgeons Ignore скачать в хорошем качестве

Vitamin D & Implant Failures: The Hidden Variable Surgeons Ignore

Are your “mystery” implant failures truly random—or are you placing implants into vitamin D deficiency? This video breaks down the emerging connection between low serum 25-hydroxy-vitamin D, early implant loss, and delayed or incomplete graft healing. No hype—just human evidence, animal data, and the biologic mechanisms implant surgeons actually need to understand. You’ll also get a simple, repeatable workflow you can plug straight into your surgical assessment. What you’ll learn: • Why multiple human studies show higher early failure rates in vitamin-D-deficient patients • How vitamin D drives macrophage behaviour, LL-37 expression, angiogenesis, and bone remodelling during osseointegration • What animal models reveal about graft healing under deficient vs adequate vitamin D levels • Practical serum cut-offs for deficiency, insufficiency, and sufficiency in a surgical setting • A step-by-step protocol to screen, correct, and maintain vitamin D in high-risk implant and grafting patients • Why sunlight is unreliable in the UK and cannot be treated as a clinical protocol Clinical takeaway: Vitamin D won’t fix poor surgery—but deficiency is a modifiable systemic risk that directly affects the biology your implants rely on. Build it into your assessment. Stop leaving it to chance. Chapters: 00:00 Intro 01:22 Human Evidence - a signal you can't ignore 02;28 The Biology - why deficiency hurts osseointegration 04:23 The Grafting Angle - where it really shows 05:34 Thresholds - general health vs surgical reality 06:59 Practical Workflow - how to build this into your system 08:40 Sunlight - the biological ceiling 09:35 Hype VS Reality #VitaminD #DentalImplants #ImplantDentistry #OralSurgery #ImplantSurgery #Osseointegration #BoneHealing #BoneGrafting #DentalGrafting #ImplantComplications #PeriImplantitis #Implantology #DentalEducation #DentalCPD #ImplantTraining #RegenerativeDentistry #Osteoimmunology #DentalResearch #OralImplants REFERENCES: Implant / graft / clinical evidence 1. Mangano FG, et al. Low serum vitamin D and early dental implant failure: retrospective study of 1740 implants. J Dent Res Dent Clin Dent Prospects. 2018;12(3):174–82. 2. Fretwurst T, et al. Vitamin D deficiency in early implant failure: two case reports. Int J Implant Dent. 2016;2:24. 3. Buzatu BLR, et al. Impact of vitamin D on osseointegration: systematic review. Nutrients. 2024;16(2):209. 4. Werny JG, et al. Does vitamin D affect osseointegration? Systematic review. Int J Implant Dent. 2022;8(1):16. 5. Tallon E, et al. Vitamin D, bone metabolism, and implant failure: umbrella review. Healthcare (Basel). 2024;12:1867. 6. Low Serum Vitamin D and Early Dental Implant Failure: systematic review. Cureus. 2022;14(1):eXXXX. 7. Iqbal A, et al. Effect of vitamin D on implant osseointegration. Ann Abbasi Shaheed Hosp Karachi Med Dent Coll. 2024;XX(X):XX–XX. 8. Diachkova E, et al. Vitamin D3 and osseointegration: rabbit model. J Orthop Res. 2024;42(2):XX–XX. 9. Diachkova E, et al. Implant rehabilitation in patients with vitamin D imbalance: RCT. Appl Sci. 2025;15(17):9490. 10. Hacibektasoglu MS, et al. Systemic vitamin D and graft healing: experimental histology. Appl Sci. 2024;14(2):939. Vitamin D biology, immune modulation, LL-37 11. Ao T, Kikuta J, Ishii M. Vitamin D effects on immune regulation and inflammation. Biomolecules. 2021;11(11):1624. 12. Wasnik S, et al. Active vitamin D suppresses M1 and promotes M2 macrophages at bone injury sites. JCI Insight. 2018;3(23):e98773. 13. Vaccaro JA, et al. Cathelicidin mediates the anti-inflammatory effects of vitamin D. Front Cell Infect Microbiol. 2022;12:875772. 14. Khurshid Z, et al. Role of antimicrobial peptides in oral health. Biomolecules. 2017;7(4):80. Guidelines and thresholds 15. Holick MF, et al. Evaluation and treatment of vitamin D deficiency: Endocrine Society guideline. J Clin Endocrinol Metab. 2011;96(7):1911–30. 16. Demay MB, et al. Vitamin D for disease prevention: Endocrine Society guideline. J Clin Endocrinol Metab. 2024;109(8):1907–47. 17. SACN. Vitamin D and health. Public Health England; 2016. 18. NHS. Vitamin D: recommended intake. Updated 2024.