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In this episode of the Flex Diet Podcast, I’m joined by my good friend Dr. Eric Trexler, exercise scientist, educator, and Director of Education at Stronger by Science, for a wide-ranging, no-BS conversation on what physiology actually looks like in the real world. We dig into beetroot juice, nitric oxide, and “pump” supplements, why the blood-flow story is usually oversold, and why neuromuscular function and calcium handling may matter far more than chasing a swollen muscle. We also talk about why most supplement mechanisms sound great on paper… and quietly fall apart once you look at healthy humans who already function pretty well. From there, the conversation expands into human variability, elite athletic outliers, and why normal distributions actually guarantee that “freaks” exist — whether people are comfortable admitting it or not. We also unpack NEAT, energy expenditure, and why exercise doesn’t scale linearly for fat loss, including how the body aggressively manages its energy budget when stress or activity gets too high. If you care about performance, body composition, or just understanding how the human system really works, this episode will recalibrate a lot of assumptions. Sponsors: LMNT: http://drinklmnt.com/mikenelson (automatically applied at checkout) Fitness Insider Newsletter: https://miketnelson.com/ Shiftwave: https://shiftwave.co/drmiketnelson Episode Chapters: 05:01 Diving into Beet Root and Nitrate Research 05:58 Mechanisms and Effects of Nitrate Supplements 10:14 Challenges and Insights in Supplement Research 34:19 Elite Athletes and Physiological Variability 43:16 Debating the Value of Outliers in Research 44:38 The Importance of Studying Rare Genetic Conditions 45:46 Challenges in Grant Writing for Rare Conditions 47:39 Blood Flow and Muscle Performance 49:14 The Science Behind Muscle Pumps and Hypertrophy 56:09 Energy Expenditure and Physical Activity 58:02 The Non-Linear Relationship Between Activity and Energy Intake 01:01:28 Exercise, Appetite, and Weight Management 01:14:19 Balancing Cardio and Strength Training for Optimal Health 01:21:14 Closing Remarks and Resources Episodes You Might Enjoy: Episode 352: Dr. Dan Pardi on Stem Cells, Supplements, and the Future of Health with Qualia YouTube: • Dr. Dan Pardi on Stem Cells, Supplements, ... Episode 343: Fueling the Corporate Athlete: Stress, Supplements & Performance with Dan Hunter YouTube: • Fueling the Corporate Athlete: Stress, Sup... Connect with Eric: Instagram: / trexlerfitness Get In Touch with Dr Mike: Instagram: / drmiketnelson YouTube: / @flexdietcert Email: https://miketnelson.com/contact-us/