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Legacy workflows in toxicology generally involve a drug class screen followed by a gas chromatography/mass spectroscopy (GC/MS) and liquid chromatography mass spectroscopy (LC/MS-MS) confirmation analysis. Additional techniques could also be used in workflows, but their applications were focused on specific drugs. In general, analyses were serial, limited, and often required multiple methods depending on the number of drug classes in the samples. Results required lengthy and costly workflows, especially when toxicologists were working with complicated samples. This webinar was presented by the NIJ Forensic Technology Center of Excellence on February 6, 2020. (Opinions or points of view expressed represent the speaker and do not necessarily represent the official position or policies of the U.S. Department of Justice. Any product or manufacturer discussed is presented for informational purposes only and do not constitute product approval or endorsement by the U.S. Department of Justice.)