[Cell, 2025] DNA's Hidden Switch: How KDM6B Unlocks Genes скачать в хорошем качестве

[Cell, 2025] DNA's Hidden Switch: How KDM6B Unlocks Genes

00:00 Channel Intro 00:41 Start 16:50 End Ever wondered how your cells switch genes on and off? Histone H3 lysine 27 trimethylation (H3K27me3) is a repressive mark, keeping genes silenced by compacting DNA into heterochromatin. But how do cells reverse this "off" switch? A new cryo-EM study, "Structural mechanism of H3K27 demethylation and crosstalk with heterochromatin markers", reveals how the enzyme KDM6B removes this mark. Published in Molecular Cell (August 7, 2025) by Chien-Chu Lin and colleagues, the research shows KDM6B engages nucleosomal DNA and linkers to position its catalytic domain for H3K27 demethylation. KDM6B even compacts the DNA, suggesting it's built to operate in dense chromatin. This research is vital as it explains KDM6B's role in reactivating silenced chromatin. It highlights that linker histones and H2AK119ub1, common in heterochromatin, antagonize KDM6B, meaning they must be removed for H3K27me3 erasure and gene activation. Understanding these mechanisms is crucial for developing therapies for diseases like cancer where KDM6B is often dysregulated. Full paper: https://doi.org/10.1016/j.molcel.2025.... Authors: Chien-Chu Lin, Yani Zhao, Caroline A. Foley, Aspen T. Hawkins, Lindsey I. James, Stephen V. Frye, Robert K. McGinty. Subscribe for more science insights! Like this video, and share your thoughts below!