Blistering disorder@ Pemphigus # pemphigoid# SJS / INI cet скачать в хорошем качестве

Blistering disorder@ Pemphigus # pemphigoid# SJS / INI cet

Blistering Disorders – Dermatology Notes (NEET PG) 1. Classification • Intraepidermal blister: Pemphigus group • Subepidermal blister: Pemphigoid group, Dermatitis herpetiformis, Linear IgA disease 2. Pemphigus Vulgaris (Most Important) 1 Autoimmune against Desmoglein 3 (± Desmoglein 1) 2 Intraepidermal, suprabasal blister 3 Flaccid bullae, easily rupture → erosions 4 Oral mucosa involved early 5 Nikolsky sign: Positive 6 Tzanck smear: Acantholytic cells 7 DIF: Fish((net IgG in epidermis 8 Treatment: Systemic steroids + Rituximab / immunosuppressants 3. Bullous Pemphigoid 1 Autoimmune against Hemidesmosomes (BP180, BP230) 2 Subepidermal blister 3 Tense bullae, less rupture 4 Mucosal involvement uncommon 5 Nikolsky sign: Negative 6 DIF: Linear IgG along basement membrane 7 Treatment: Steroids (topical/systemic) 4. Key Differences – Exam Table Feature Pemphigus Vulgaris Bullous Pemphigoid Level Intraepidermal Subepidermal Bullae Flaccid Tense Mucosa Common Rare Nikolsky Positive Negative DIF Fish((net Linear BMZ