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(1 Aug 2022) ITALY COVID-19 CHILDREN SOURCE: ASSOCIATED PRESS RESTRICTION SUMMARY: LENGTH: 5.02 ASSOCIATED PRESS Rome, Italy - 26 July 2022 1. Lorenza Romani, paediatrician, and Lorenza Putignani, head of human microbiome research lab, entering Bambino Gesù hospital laboratories 2. Laboratory technician fill up tube 3. Tilt up from tubes to Romani and Putignani chatting 4. Romani and Putignani talking about their research 5. Front page of scientific article published on 'Frontiers in cellular and infection microbiology', headline reading "The Relationship Between Paediatric Gut Microbiota and SARS-CoV-2 Infection" 6. SOUNDBITE (Italian), Lorenza Romani, infectious diseases paediatrician at Bambino Gesù hospital in Rome: "For us the greatest news was the evidence of a sharply increased presence of a bacterium in the children's (faecal) microbiome compared with healthy patients. But most important of all, this bacterium is described as totally absent in adult COVID-19 patients. In fact, with adults the lower the presence of the bacterium, the greater the severity of the symptoms." 7. Romani and Putignani talking about research 8. Close up of percentages of bacteria in children affected by COVID-19 9. SOUNDBITE (Italian), Lorenza Romani, infectious diseases paediatrician at Bambino Gesù hospital in Rome: "This bacterium, which is called Faecalibacterium, is capable of keeping an homeostasis inside the intestine and therefore capable of guaranteeing a functionally good intestinal barrier and, above all, of providing an anti-inflammatory function. So, obviously when it comes to seriously ill adult patients when this bacteria is absent we also lose an important defence for the whole immune system." 10. Researchers entering laboratory 11. Pull focus from Lorenza Putignani to computer's screen. 12. Putignani's team of researchers working on their computers. 13. Close of computer's screen 14. SOUNDBITE (Italian), Lorenza Putignani, head of human microbiome research lab at Bambino Gesù hospital in Rome: ''We identified Faecalibacterium prausnitzii by its ecology, but it was also actually a characteristic found by artificial intelligence. So, it means that it's a strong marker that can be linked to the illness when we compare the illness to healthy subjects." Reporter: And the illness was COVID-19? Lorenza Putignani: "And the illness was COVID-19.'' 15. List of bacteria found in children microbiome on a computer's screen, reading: Corynebacterium, Flavobacterium, Faecalibacterium, Coprococcus, Collinsella. 16. Bioinformatics researchers at their computers 17. Diagrams showing bacteria percentages in children's microbiom 18. Various of Romani and Putignani inside lab 19. Close of Bambino Gesù paediatric hospital logo 20. SOUNDBITE (Italian), Lorenza Romani, infectious diseases paediatrician at Bambino Gesù hospital in Rome: ''Well, for sure, starting from the natural features of this bacterium we can hypothesize the use of second generation probiotics which contain Faecalibacterium. This is one of the possible therapeutical options to be evaluated firstly among the adult population, and then in the future we can even hypothesize a microbiome transplant, a faecal (microbiome) transplant, using children as donors, since they are both rich in it (the bacterium) and they evidently have far less severe symptoms than the adults.'' 21. Various of Romani and Putignani talking about microscope analysis 22. Various of Putignani's lab team of researchers 23. SOUNDBITE (Italian), Lorenza Putignani, head of human microbiome research lab at Bambino Gesù hospital in Rome: LEADIN: Find out more about AP Archive: http://www.aparchive.com/HowWeWork Twitter: / ap_archive Facebook: / aparchives Instagram: / apnews You can license this story through AP Archive: http://www.aparchive.com/metadata/you...