9: Glycation and Kindey Health: From Damage to Dialysis with Dr. Paul Reynolds скачать в хорошем качестве

9: Glycation and Kindey Health: From Damage to Dialysis with Dr. Paul Reynolds

In this essential episode of the College of Glycation series, Dr. Paul Reynolds—Professor of Cell Biology and Physiology—unpacks the critical yet underappreciated link between glycation and kidney health. Building on prior episodes that explored glycation’s role in aging and metabolic damage, this lecture exposes how advanced glycation end products (AGEs) sabotage your kidneys—leading to proteinuria, inflammation, and ultimately, chronic kidney disease and dialysis. Through vivid explanations and cutting-edge studies, Dr. Reynolds reveals how AGEs silently attack the kidney’s filtration system, activate destructive inflammation through the RAGE receptor, and trigger irreversible scarring. Combined with insulin resistance and poor blood sugar control, glycation becomes a metabolic wrecking ball—especially in people with diabetes. This is more than a diabetic complication—it’s a global epidemic in the making. You’ll also learn how glycation research evolved—from early discoveries in the 1980s to today’s promising use of non-invasive biomarkers like skin autofluorescence and emerging anti-AGE therapies. Most importantly, this episode arms you with actionable steps to reduce AGE burden, improve insulin sensitivity, and protect your kidneys through diet and lifestyle. Topics Covered: -What glycation is and how AGEs form -How AGEs impair kidney filtration and trigger proteinuria -Inflammatory damage via RAGE and cytokines -The role of fibrosis and scarring in chronic kidney disease (CKD) -How insulin resistance accelerates glycation and kidney damage -Non-invasive AGE detection through skin autofluorescence -Lifestyle and dietary strategies to protect kidney health Timestamps: 00:00 – Introduction to the College of Glycation 01:22 – Glycation and its impact on kidney function 02:43 – What are AGEs (advanced glycation end products)? 04:09 – How glycation disrupts kidney anatomy and function 05:29 – Filtering problems and proteinuria explained 06:55 – Inflammation and the role of RAGE receptors 08:27 – Fibrosis and long-term kidney scarring 09:52 – Broader effects: cardiovascular impact and insulin resistance 11:17 – Insulin resistance and its role in kidney damage 13:25 – Scientific evidence linking glycation to kidney decline 14:45 – Practical strategies to protect kidney health 16:21 – Cooking methods to reduce dietary AGEs 17:37 – Antioxidants, blood pressure, and vascular protection 19:01 – History of AGE research and detection tools 20:33 – Clinical support for low-AGE diets in CKD 22:00 – Summary and actionable takeaways 22:40 – Final thoughts and wrap-up Whether you're managing diabetes, concerned about kidney function, or simply looking to safeguard long-term health, this episode offers the tools and insights you need. About Dr. Paul Reynolds Dr. Reynolds is a biomedical scientist and renowned educator at Brigham Young University. Known for breaking down complex metabolic pathways into clear and engaging insights, he leads the College of Glycation series to empower people against the silent molecular processes behind chronic disease. #Glycation #AGEs #inflammation #OxidativeStress #ROS #Redox #CollegeOfGlycation #Kidney #KidneyDisease #RenalFailure #KidneyHealth #Dialysis #Ketodiet #LowCarb #InsulinResistance #HealthyAging #SugarDamage #HealthyLiving #HealthPodcast #AntiAging #Nutrition #BiomedicalScience #BloodSugar #Wellness #HealthTips #SciencePodcast #HealthyEating #CellularHealth #PodcastEpisode #Keto #KetoCommunity #healtheducation Paul’s favorite yerba mate: https://ufeelgreat.com/usa/en/c/C63EE3 Paul’s favorite exogenous ketones: A high-quality option is the NSF-certified goBHB from Clean Form Nutrition, where you can use the code Paul10 for a 10% discount: https://cleanformnutrition.com/produc... Paul’s favorite allulose source: https://rxsugar.com (discount: PAUL20) Paul’s favorite health check-up for men or women: https://blokes.co/DRPAUL (discount: DRPAUL for 50% off of labs and smart supplements and 15% off all other product)