A Better Humanized Tau Model for Alzheimer's Research | Cyagen Talk скачать в хорошем качестве

A Better Humanized Tau Model for Alzheimer's Research | Cyagen Talk

Tired of preclinical Alzheimer's models that fail to translate? This World Alzheimer's Month, we're addressing a critical reason why the search for a cure is so challenging: the models we use.  In this episode of Cyagen Talk, our founder Lance Han and scientist Morris Cui discuss the critical limitations of traditional tau models and unveil a superior solution that accurately recapitulates human disease. This is a must-watch for researchers and drug developers focused on advancing diagnostics and therapeutics for Alzheimer's and other tauopathies. ▶ Explore the HUGO-GT™ Models Discussed in This Video: https://www.cyagen.com/cro-services/n... 💡 IN THIS VIDEO, YOU WILL LEARN: ● The 3R vs. 4R Tau Problem: Understand why mouse models, which only express 4R tau, are not ideal for human diseases like Alzheimer's. ● A Complete Humanized Solution: Discover the HUGO-Tau™ model, created with our advanced TurboKnockout® technology, which replaces the entire mouse MAPT gene with the human sequence. ● Exclusive 9-Month Study Data: See compelling behavioral and pathological evidence from our P301S & P301L models that mirrors human patient timelines. ● Accelerating Therapeutics: Learn how this model is a vital tool for developing next-gen diagnostics and safer, more effective tau-targeting treatments. ▶ Subscribe to get more insights! In our last episode, we covered the "One Model Fits All" future of gene therapy:    • The "One Model Fits All" Future of Gene Th...   *CHAPTERS*: 00:09 - The 99% Failure Rate in Alzheimer's Drug Development 05:26 - Aβ vs. Tau: The Critical Shift in Alzheimer's Research 11:18 - Why Mouse Tau Fails: The Critical 3R/4R Isoform Difference 20:45 - Introducing the HUGO™ Platform & TurboKnockout® 24:51 - Study Part 1: Age-Dependent Cognitive Deficits (Behavioral Data) 32:06 - Study Part 2: Recapitulating Human Tauopathy (Pathology Data) 37:25 - Application 1: A Powerful Tool for Better Diagnostics 47:12 - Application 2: Designing Safer Tau-Targeting Therapeutics 50:07 - What's Next? Humanized Models for Parkinson's (SNCA) & APP This video provides critical insights for researchers, PIs, and drug developers in biotech and pharma focusing on Alzheimer's disease, frontotemporal dementia (FTD), and other tauopathies. Our discussion covers preclinical models, in vivo studies, neurodegeneration, and translational research for key targets like MAPT (Tau), P301S, and P301L. ※ The products and services described are for research use only. #AlzheimersResearch #Tauopathy #HumanizedMouseModel #PreclinicalStudies #Neurodegeneration #Cyagen #DrugDevelopment #Genetics