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PSMA-PET prostate cancer IAEA staging protocols nuclear medicine gallium-68 PET/CT MRI high-risk prostate cancer metastatic disease radical prostatectomy lymph node metastases seminal vesicle invasion. In this video, we dive into the groundbreaking IAEA-sponsored trial published in the Journal of Nuclear Medicine, showing how PSMA-PET outperforms MRI in staging high-risk prostate cancer. Led by researchers from Quanta Diagnostics and Therapy, the study involved 775 men across 11 countries, including low-, middle-, and high-income nations, proving PSMA-PET's accuracy in detecting metastases and altering treatment plans. Discover how this imaging technique prevents unnecessary surgeries and supports global adoption into standard protocols. We break down the key findings, such as PSMA-PET's 90% accuracy for seminal vesicle invasion versus MRI's 57%, and 91% for lymph node metastases. Learn about the challenges in low-income countries and ongoing cost-effectiveness analyses. Perfect for medical professionals, patients, and anyone interested in advancements in cancer diagnostics.