Metabolism | Mobilization of Triglycerides скачать в хорошем качестве

Metabolism | Mobilization of Triglycerides

Official Ninja Nerd Website: https://ninjanerd.org Ninja Nerds! In this metabolism lecture, Professor Zach Murphy explains the Mobilization of Triglycerides, the critical process by which stored fat in adipose tissue is broken down into free fatty acids and glycerol to meet the body’s energy demands during fasting, stress, or prolonged exercise. This lecture bridges the gap between fat storage and energy utilization by highlighting the hormonal signals, key enzymes, and physiologic triggers involved. We begin by discussing how epinephrine, glucagon, and cortisol activate hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) through cAMP-mediated signaling pathways. These enzymes catalyze the stepwise hydrolysis of triglycerides into free fatty acids and glycerol, which are then released into the bloodstream and transported to tissues like the liver, skeletal muscle, and heart for β-oxidation. The lecture also covers the role of albumin in transporting free fatty acids in plasma and how insulin, in contrast, inhibits lipolysis by activating phosphodiesterase and promoting HSL dephosphorylation. We reinforce how triglyceride mobilization supports gluconeogenesis and ketogenesis during prolonged fasting, ensuring energy availability for glucose-dependent tissues. Enjoy the lecture and support us below! 🌐 Official Links Website: https://www.ninjanerd.org Podcast: https://podcast.ninjanerd.org Store: https://merch.ninjanerd.org 📱 Social Media   / ninjanerdlectures     / ninjanerdlectures     / ninjanerdlectures   https://x.com/ninjanerdsci/   / ninja-nerd   💬 Join Our Community Discord:   / discord   #ninjanerd #TriglycerideMobilization #Metabolism