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As interest in personalized nutrition grows, AI and metabolomics are enabling scientists to examine foods at unprecedented molecular depth. This Hot Topics Studio discussion from IFT FIRST 2025, featuring Josette Lewis (Vice President and Chief Scientific Officer, Research & Innovation at the Almond Board of California) and Clay Bloszies (Associate Director, Metabolomics at Brightseed) shared how emerging AI and metabolomics technologies are uncovering novel bioactives in almonds with promising implications for personalized health. This session highlights cutting-edge research using advanced analytical tools to identify six previously unidentified bioactive compounds in almonds with links to brain, immune, metabolic, and gut health, as well as cellular aging. Learn how these findings are shaping the future of functional food innovation and opening new doors for health-focused product development.