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A 41-year-old woman presents with recurrent right foot drop, lateral knee pain, dorsiflexion weakness, and a palpable cyst near the fibular head, with symptoms returning after previous interventions. On exam, she has sensory loss over the dorsum of the foot, muscle weakness, and a fluctuant mass. What underlying mechanisms explain these persistent neurological deficits, and what clinical features help distinguish the cause of these relapsing symptoms? VIDEO INFO Category: Peripheral Neuroanatomy, Human Anatomy, USMLE Step 1 Difficulty: Expert - Expert level - For those seeking deep understanding Question Type: Treatment Failure Case Type: Complicated Condition Explore more ways to learn on this and other topics by going to https://endlessmedical.academy/auth?h... QUESTION A 41-year-old woman presents to a peripheral nerve clinic for recurrent right foot drop and lateral knee pain. For several months she has had intermittent dorsiflexion weakness that improved transiently after aspiration of a cyst near the fibular head but recurred within weeks. Two years ago, she had osteomyelitis of the calcaneus that was successfully treated and has not recurred.... OPTIONS A. Perform microsurgical neurolysis of the common fibular (peroneal) nerve with identification and disconnection (ligation/resection) of the articular branch to the superior tibiofibular joint plus resection/disarticulation of the involved STFJ, as an outpatient procedure. B. Perform microsurgical neurolysis with identification and disconnection of the articular branch while preserving the superior tibiofibular joint, as an outpatient procedure. C. Resect or disarticulate the superior tibiofibular joint without tracing and disconnecting the intraneural articular branch, performed as outpatient surgery. D. Excise the intraneural cyst through an epineurial window with primary neurorrhaphy, leaving the superior tibiofibular joint and articular branch intact, as an outpatient procedure. CORRECT ANSWER A. Perform microsurgical neurolysis of the common fibular (peroneal) nerve with identification and disconnection (ligation/resection) of the articular branch to the superior tibiofibular joint plus resection/disarticulation of the involved STFJ, as an outpatient procedure. EXPLANATION Perform microsurgical neurolysis of the common fibular (peroneal) nerve with identification and disconnection (ligation/resection) of the articular branch to the superior tibiofibular joint plus resection/disarticulation of the involved STFJ, as an outpatient procedure. Recurrent peroneal intraneural ganglion after decompression and aspiration reflects persistent joint-nerve communication described by the articular (unified) theory: synovial fluid tracks from the superior tibiofibular joint via the articular branch into the peroneal nerve, dissecting intraneurally. Durable cure therefore requires addressing both conduits-the articular branch and its joint of origin-in addition to neurolysis. Imaging and electrodiagnostics show a joint-connected intraneural cyst with focal conduction block at the fibular tunnel, matching classic patterns reported by expert series. Close alternatives each omit one critical step. Disconnecting the articular branch but leaving the superior tibiofibular joint intact risks re-pressurization and recurrence via residual capsular defects or microchannels. Resecting or disarticulating the joint without tracing and disconnecting the intraneural articular branch leaves a persistent pathway.... --------------------------------------------------- Our cases and questions come from the https://EndlessMedical.Academy quiz engine - multi-model platform. Each question and explanation is forged by consensus between multiple top AI models (GPT, Claude, Grok, etc.), with automated web searches for the latest research and verified references. Calculations (e.g. eGFR, dosages) are checked via code execution to eliminate errors, and all references are reviewed by several AIs to minimize hallucinations. Important note: This material is entirely AI-generated and has not been verified by human experts; despite stringent consensus checks, perfect accuracy cannot be guaranteed. Exercise caution - always corroborate the content with trusted references or qualified professionals, and never apply information from this book to patient care or clinical decisions without independent verification. Clinicians already rely on AI and online tools - myself included - so treat this book as an additional focused aid, not a replacement for proper medical education. Visit https://endlessmedical.academy for more AI-supported resources and cases. This material can not be treated as medical advice. May contain errors. ---------------------------------------------------