Antifungals - Module 1 - The Basics First: Logical Overview (NEET PG, NEET SS, MRCP, Physicians) скачать в хорошем качестве

Antifungals - Module 1 - The Basics First: Logical Overview (NEET PG, NEET SS, MRCP, Physicians)

"Why does Micafungin kill Candida but fail against Cryptococcus? Why is Amphotericin B the only drug that works for everything, but at a terrible cost?" Welcome to Episode of the Antibiotic Mastery Series on Medicine Beyond Harrison's. In this episode, we tackle Antifungal Pharmacology. Unlike bacteria, fungi are Eukaryotes—sharing ribosomes, mitochondria, and nuclei with humans. This biological similarity makes designing safe drugs incredibly difficult. We move beyond rote memorization of spectrum tables to a Biological Logic framework. By understanding the four pillars of fungal survival, you can predict the activity of any drug without looking it up. We cover the complete clinical profile: The Eukaryotic Problem: Why the shared biology between humans and fungi creates a narrow therapeutic window and high toxicity risks. The 4 Survival Pillars: Cell Membrane (Ergosterol), Cell Wall (Beta-Glucan), Nuclear Function (DNA), and Mitosis. Azoles (Fluconazole/Voriconazole): Why they are "Enzyme Inhibitors" (CYP51), not structural destroyers, and why this makes them vulnerable to resistance in C. glabrata and C. krusei. Echinocandins (Caspofungin/Micafungin): The "Penicillins of the Fungal World"—why they are so safe (humans lack cell walls) but fail against Cryptococcus (capsule masking) and Mucorales (chitin dominance). Amphotericin B: The "Brute Force" agent—why physical pore formation works against almost everything, but comes with unavoidable renal toxicity. The Mental Model: A rapid bedside algorithm to choose between Azoles (Stable Yeast), Echinocandins (Critically Ill Yeast), and Amphotericin (Invasive Mold). This video provides the fundamental reasoning required to treat invasive fungal infections with precision rather than guesswork. REFERENCES & GUIDELINES: IDSA Clinical Practice Guidelines for the Management of Candidiasis "Antifungal Agents: Mechanisms of Action" - Trends in Microbiology The Sanford Guide to Antimicrobial Therapy (Antifungal Section) Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases ESCMID Guidelines for Invasive Aspergillosis ABOUT THE CHANNEL: Medicine Beyond Harrison's is for the discerning physician who wants to understand the pathophysiology behind the protocol. We bridge the gap between standard guidelines and the complex reality of the wards. No fluff, just pure internal medicine. Antifungal Mechanism of Action, Echinocandin Spectrum of Activity, Amphotericin B Mechanism Pore Formation, Azole Antifungal Resistance Mechanism, Candida Glabrata Treatment, Cryptococcus Treatment Guidelines, Mucormycosis Treatment, Fungal Cell Wall Structure, Ergosterol Synthesis Inhibitors, Invasive Candidiasis Guidelines, Internal Medicine Residency, NEET SS Medicine, Critical Care Pharmacology, Infectious Disease Fellowship, Mycology for Physicians #Antifungals #Pharmacology #InfectiousDiseases #CriticalCare #MedicalEducation #MedicineBeyondHarrisons #NEETSS #MRCP #Mycology #Candida #Amphotericin #Echinocandins #Azoles #HospitalMedicine #FungalInfection