Enabling Binder and Molecular Glue Discovery with High-Throughput Spectral Shift Technology скачать в хорошем качестве

Enabling Binder and Molecular Glue Discovery with High-Throughput Spectral Shift Technology

Speakers: • Vanessa Porkolab, PhD - Biophysics Director, Eurofins Discovery • Maud Sigoillot, PhD - Biophysics Study Director, Eurofins Discovery Discover how High-throughput Spectral Shift (HT-SpS) technology accelerates binder and molecular glue discovery for some of the most challenging targets, including proteins with allosteric sites and complex protein–protein interactions. This is enabled by a high-throughput, affinity-based workflow powered by the Dianthus uHTS (NanoTemper®) and seamlessly integrated with Genedata Screener® for automated data processing and analysis. Key Areas Covered: • How HT-SpS scales early hit-finding to 65,000+ data points per day with minimal protein input and no immobilization. • Why HT-SpS is uniquely powerful: a site-agnostic, affinity-based alternative that complements or outperforms AS-MS and DEL for challenging targets. • PIM3 kinase case study demonstrates how HT-SpS identifies new chemical spaces not previously accessible through conventional HTS approaches. • Using CRBN as the E3 ligase, HT-SpS detects and characterizes binary and ternary complexes, showcasing its ability to identify molecular glues. For more about our Biophysics expertise, click here: https://emea.eurofinsdiscovery.com/so... #Eurofins #EurofinsDiscovery #DrugDiscovery #Biophysics #SpectralShift #HighThroughputScreening #MolecularGlue #AffinityScreening “Key Moment/Chapters”: • Introduction: 0:00 – 5:08 • Presentation HT-SpS: 5:08 – 10:37 • Case Studies: 10:38 – 34:12