Karen L. Goldenberg - Organometallic Complexes and Molecular Oxygen скачать в хорошем качестве

Karen L. Goldenberg - Organometallic Complexes and Molecular Oxygen

2024 Welch Conference: "Frontiers in Molecular Catalysis" Karen Goldberg is the Vagelos Professor in Energy Research and Chemistry, and the inaugural Director of the Vagelos Institute for Energy Science and Technology at the University of Pennsylvania (Penn). She earned her A.B. in chemistry from Barnard College and her Ph.D. in chemistry from the University of California, Berkeley. Following postdoctoral study at The Ohio State University, Goldberg joined the faculty at Illinois State University, a primarily undergraduate institution, and then in 1995, moved to the University of Washington (UW) in Seattle. At UW, Goldberg was the Nicole A. Boand Endowed Professor in Chemistry and from 2007-2017, served as Director of the first NSF Phase II Center for Chemical Innovation, the Center for Enabling New Technologies through Catalysis (CENTC). In 2017, she moved to her current position at Penn. Goldberg is best known for her work developing mechanistic understanding of fundamental organometallic reactions and for application of that knowledge to the creation and optimization of new catalytic systems. Goldberg is a Fellow of the American Association for the Advancement of Science (AAAS) and of the American Chemical Society (ACS). She received the ACS Award for Organometallic Chemistry in 2016 and has been elected to the American Academy of Arts and Sciences and the National Academy of Sciences. More than 75 graduate students and postdoctoral research associates and over 70 undergraduate students have trained in her laboratories. Abstract: Organometallic Complexes and Molecular Oxygen – Developing Mechanistic Understanding Molecular oxygen represents the ideal oxidant to use in chemical oxidation reactions. It is abundantly available, inexpensive (particularly if used without separation from air) and environmentally benign. However, more expensive and/or hazardous oxidants are more often employed in homogeneous metal-catalyzed organic oxidations. A limiting factor in the development of organometallic catalytic systems for aerobic oxidations has been a lack of mechanistic understanding of how transition metal complexes react with molecular oxygen. For years, organometallic chemists have been highly successful in applying the vast wealth of fundamental mechanistic understanding of the reactions of transition metal complexes with small molecules like CO and olefins, to develop catalysts for selective carbonylations, hydrogenations, polymerizations and more. In contrast, perhaps due to the rigor with which organometallic chemists protect their compounds from the atmosphere, that same level of mechanistic understanding of the reactions of transition metal complexes with O2 is lacking, inhibiting the development of effective catalytic systems for aerobic oxidations. In this presentation, detailed kinetic and mechanistic studies of the reactions of molecular oxygen with a variety of late metal alkyl and hydride complexes will be presented along with our nascent understanding of the generalities and limits of the mechanistic pathways available. The opportunities and potential for the incorporation of such reactions into hydrocarbon functionalization strategies will also be discussed. Learn more about The Welch Conference: https://welch1.org/conference/confere...