Regional Tau Asymmetry / Chronic Jet Lag & Developing Brain | Neurology Grand Rounds скачать в хорошем качестве

Regional Tau Asymmetry / Chronic Jet Lag & Developing Brain | Neurology Grand Rounds

Recorded live on May 3rd, 2024 In this recorded Neurology Grand Rounds combined Resident research presentation, Dr. Nick Schwartz from Beth Mormino's lab presents on regional tau asymmetry in PET imaging for Alzheimer's disease. He discusses the importance of tau PET imaging, its advantages over amyloid PET, and his research on tau asymmetry. Dr. Schwartz analyzes data from ADNI and A4 studies, focusing on six brain regions. He found that laterality index increases with age but decreases with increased amyloid. Laterality seems to worsen MOCA scores in clinically unimpaired patients and potentially affects cognitive domains in dementia stages. His research suggests a model where individuals gain laterality over time, reach a maximum, then revert to a more symmetrical state, possibly mediated by increased amyloid. He then expresses plans to further investigate this in other cohorts and apply machine learning techniques. In the second part of the combined Resident research lecture, Dr. Ann Robbins presents research on circadian rhythms in the oligodendrocyte lineage, conducted in Erin Gibson's lab. She provides an overview of the circadian system, its disruption effects, and focused on the oligodendrocyte lineage. Dr. Robbins discusses ongoing experiments using a chronic jet lag model in pregnant mice to study the effects of circadian disruption on oligodendrocyte precursor cells (OPCs) and myelination in offspring. Preliminary results showed increased OPC proliferation but similar cell density in the corpus callosum of mice subjected to chronic jet lag in utero. Dr. Robbins emphasizes the need for further replication and investigation of these findings, including additional models of circadian misalignment and further histology and electron microscopy studies. Claim CE credit at: https://stanford.cloud-cme.com/course... Learning Objectives: 1. Discuss the findings on laterality and total tau in study cohorts 2. Investigate clustering properties of tau asymmetry 3. Apply machine learning techniques to further analyze tau asymmetry data 4. Discuss preliminary results on increased OPC proliferation in mice subjected to chronic jet lag in utero. 5. Implement an irregular light-dark cycle model based on human sleep data to study circadian misalignment. 6. Review histology and electron microscopy studies to examine cell types, cell numbers, and myelination in mice subjected to circadian stress. Mitigation of Relevant Financial Relationships Stanford Medicine adheres to the Standards for Integrity and Independence in Accredited Continuing Education. For full disclosure information, please visit: https://stanford.cloud-cme.com/course...