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In this conversation, Daniel Belkin and Mitch Belkin speak with Joel Topf, MD, about contrast-associated nephropathy. We discuss Acute Kidney Injury (AKI), the value of creatinine as a marker for AKI, how to evaluate volume status, the evidence around contrast-induced/contrast-associated nephropathy, recommendations on fluids to prevent AKI in patients with Chronic Kidney Disease, and comparing venous and arterial contrast with respect to the risk of AKI. Who is Joel Topf? Dr. Topf is a clinical nephrologist in Detroit, who is a partner and medical director at St Clair Nephrology and an assistant professor at Oakland University William Beaumont School of Medicine. He is the co-creator of NephMadness and NephJC. He hosts multiple podcasts, blogs at pbfluids.com, and tweets @Kidney_boy. 00:15 - Introduction: Joel Topf’s Background 03:19 - What is Acute Kidney Injury (AKI)? 08:16 - What is the value of creatinine as a marker of acute kidney injury? 12:22 - Joel Topf’s Bayesian Workup for AKI 16:14 - How to evaluate volume status (history, physical exam, FeNa, urine-lytes, POCUS)? 25:58 - Does Venous Contrast cause AKI? 35:07 - Definition of Contrast-Induced Nephropathy/ Contrast-Associated AKI 42:51 - Uptodate: Recommendations on fluids to prevent AKI in patients with Chronic Kidney Disease 45:30 - Comparing venous and arterial contrast with respect to the risk of AKI 50:24 - The PRESERVE Trial: Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine 52:52 - Rapid Fire Questions (Favorite Segment of the Nephron, Favorite Electrolyte, Important Papers in Nephrology, RCT Dr Topf wants to fund, Medical Truths that Dr. Topf Doesn’t Believe in) For more info: Check out: https://externalmedicinepodcast.com/j... Subscribe: https://bit.ly/3Qia4md Follow us on Twitter: / exmedpod