When it comes to mRNA, seeing is believing скачать в хорошем качестве

When it comes to mRNA, seeing is believing

The future of medicine is unfolding at the nanoscale. New imaging technology from UBC captures genomic medicine delivery in action, opening up avenues for drug discovery and testing. We are moving into a new era of genomic medicines that will target cancer, viruses and disease by editing our DNA and RNA. But the path to developing these drugs is not yet clear because of the incredibly small-scale drug developers are working with — our cells — and the complexity of the activities within them. “It’s a very crowded, busy, hot, dynamic environment inside our cells,” says Dr. Sabrina Leslie, a biophysicist at UBC’s Michael Smith Laboratories and department of Physics and Astronomy. “To understand how cells grow, divide and are repaired we needed to look at the interactions of the molecules within them in detail. And then at how various drugs interact with our genome at the single-cell level.” To study molecules in cell-like conditions Dr. Leslie invented a high-resolution imaging platform called Convex Lens-induced Confinement (CLiC). CLiC lets drug designers actually see the intricate workings of a cell and how they respond to nanomedicines’ drug cargos. In September 2025, she and her team took on a CEO to lead a UBC spinout company called ScopeSys to commercialize CLiC. “We’re working towards a vision where CLiC can be available in the pharmaceutical and biotech industry to help develop new medicines at the nanoscale, and also in every university in the world,” Dr. Leslie says. Learn more:   / seeing-is-believing