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In this video, I perform a critical appraisal of the PREOXI trial, and discuss the role of noninvasive positive pressure ventilation SOLELY for the purpose of preoxygenation. This paper will likely change practice for many emergency and critical care clinicians, although if you have listen to my RSI and then they die lecture ( • RSI and then they die (How to intubate sic... ), you will know that I have been recommending this for years. The major take home points from this video are: 1 This mutlicenter RCT demonstrates less peri-intubation hypoxia (as well as potentially less peri-intubation cardiac arrest) when using NIPPV for preoxygenation 2 The trial is not perfect, and there are limitations that need to be considered when applying the results clinically 3 I think the results are practice changing for many patients, but probably don’t need to be applied routinely First10EM is a free open access medical education (FOAMed) platform created and run by Dr. Justin Morgenstern dedicated to high quality education focused on resuscitation and evidence based medicine. Want more? Check out the main post on First10EM: https://first10em.com/bipap-for-preox... You can find the original paper here: https://www.nejm.org/doi/full/10.1056... Website: https://first10em.com/ Resuscitation: http://resus.first10em.com/ Evidence based medicine: https://ebm.first10em.com/ Twitter: @First10EM / first10em Facebook: / first10em Instagram: / first10em Bluesky: @first10em.bsky.social https://bsky.app/profile/first10em.bs... TikTok: / first10em Reddit: / first10em Timestamps: 00:00 Intro 03:19 The PREOXI trial 03:31 The methods 04:52 The results 06:22 Limitations 11:37 Summary Hashtags: #resuscitation #emergencymedicine #airway #criticalcare #BiPAP #evidencebasedmedicine First10EM is devoted to free, open access medical education, aimed at medical professionals. The website does not provide specific medical advice. I may be a physician, but I am not your physician. If you are a medical professional, the information should be used like any other you encounter: think critically, consider other sources of information, and ensure that you understand how the information presented here fits with your own skills, work environment, and resources. Full disclaimer: https://first10em.com/disclaimer/ I have never accepted money from any drug or device company. I have no financial conflicts of interest in any information I present. Thank you for watching! 🙂