NGBS2022 Talk 6: Atomic force microscopy uncovers invisible complexities of the genome - Alice Pyne скачать в хорошем качестве

NGBS2022 Talk 6: Atomic force microscopy uncovers invisible complexities of the genome - Alice Pyne

Uncovering the invisible complexities of the genome using atomic force microscopy Speaker: Alice Pyne, University of Sheffield, UK Chair: David Rueda, Imperial College, London/MRC-LMS, UK Co-Chair: Geoff Holdgate, AstraZeneca, UK Alice Pyne describes how she investigates the conformational dynamics of DNA using AFM. Working with manufacturers, she has driven improvements in commercial AFM cantilevers so they are uniform in size and softer which enables a step-change in the resolution and reproducibility of imaging. This has allowed her to examine the structure and dynamics of small DNA mini-circles and the effect of supercoiling and G-quadraplexes. She has also developed an automated processing pipeline software to generate quantitative AFM data that has both informed and validated MD simulations. Read more about Alice Pyne’s work here: https://pyne-lab.uk/ You can find more about the Next Generation Biophysics Symposium 2022 here: https://www3.mrc-lmb.cam.ac.uk/sites/... -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook:   / mrc.lmb   Twitter:   / mrc_lmb   Instagram:   / mrc_lmb   LinkedIn:   / mrc-laboratory-of-molecular-biology   Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambr...