Advanced Organic Chemistry: Total Synthesis of Gibberelins, Retrosynthesis, Mechanisms скачать в хорошем качестве

Advanced Organic Chemistry: Total Synthesis of Gibberelins, Retrosynthesis, Mechanisms

Gibberelins play a critical role for plants and mankind being vital factors for plant growth and agriculture. They are the reason why we avoided a global hunger wave in the 20th century, and their analogs could open new mechanisms of action against cancer! This makes synthetic access and further biochemical and pharmacological studies even more important. https://total-synthesis.com/organic-c... 🧑‍🎓➡️ Free organic chemistry practice problems   / totalsynthesis   🚀 Thanks to all channel supporters!!!   / totalsynthesis_official   👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! Please drop a like and comment to support the video's visibility, as well as activate notifications and subscribe to the channel so you do not miss out on future videos! 01:27 Gibberelin's role in nature and agriculture 04:38 Isolation of natural products 06:54 Retrosynthetic analysis and strategy 09:02 Forward synthesis and mechanisms Main paper: Concise Synthesis of (−)-GA18 Methyl Ester (Lei Li, Weida Liang, Mario E. Rivera, Ye-Cheng Wang, and Mingji Dai); https://doi.org/10.1021/jacs.2c12470 Some recommended books on organic synthesis: Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)