Oral Delivery of Paclitaxel Using a Squalene-Ligand Bioconjugate fo... | Tyler Posey | RRS Live 2024 скачать в хорошем качестве

Oral Delivery of Paclitaxel Using a Squalene-Ligand Bioconjugate fo... | Tyler Posey | RRS Live 2024

Tyler Posey is a Junior Chemistry (Pre-Med) major in the Randall Research Scholars Program (RRSP). Their research project presentation, "Oral Delivery of Paclitaxel Using a Squalene-Ligand Bioconjugate for Receptor-Mediated Targeting," was completed under the advisement of Dr Meenakshi Arora from the Center for Convergent Biosciences and Medicine Department. Project Description: Squalene is an acyclic triterpene found in shark liver oil, higher fungi, yeast, microbes, and various plant sources. As a key component in the cholesterol biosynthesis pathway, squalene has applications across cosmetics, nutraceuticals, and pharmaceuticals. FDA-approved squalene also serves as an adjuvant in parenteral drug delivery, aiding antigen transport for recognition by cells like macrophages and dendritic cells. Literature highlights the successful conjugation of cancer drugs to squalene, forming nano self-assemblies via intravenous (i.v.) administration, which enhances anticancer effects and reduces toxicity. In our research, we are adapting Dr. Patrick Couvreur's pioneering squalenoylation method to bioconjugate squalene with the anti-inflammatory ligand naringenin. This squalene-naringenin conjugate will be used to encapsulate the anticancer drug paclitaxel for oral drug delivery applications.