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The 20 min video is part of a teaching series for young clinical researches in oncology. It describes the concept and value of response evaluations in cancer trials in high level and with concrete examples. Why are response categories necessary? What is the meaning of CR or ORR? The literature example selected is for endometrial cancer, which is also explained briefly. The video is brought to you by Oncology Consulting Wolff LLC, which is solely responsible for its content. Sources are from the public domain, and listed in the video. The company has no financial conflict of interest at the time the video was produced or before. 00:00 - Introduction 02:02 - definitions of CR PR SD PD CRR ORR 06:40 - an example of a child with cancer 11:26 - publication endometrial cancer ADC treatment 13:44 - endometrial cancer Overview 16:56 - trastuzumab deruxtecan Overview